Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.49 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5403363 | 0.84 | MEN1 (0.47) | LMNAALDH1A1PTGDR2SLC22A12MEN1 | |
| SCHEMBL5835789 | 0.83 | NOTUM (0.64) | ALDH1A1NOTUM | |
| SCHEMBL221250 | 0.83 | NOTUM (0.64) | ALDH1A1NOTUM | |
| SCHEMBL6420547 | 0.81 | MCL1 (0.73) | LMNAALDH1A1MEN1KMT2AMCL1 | |
| SCHEMBL4914150 | 0.78 | HTT (0.59) | LMNAALDH1A1PTGDR2MEN1KMT2A | |
| SCHEMBL6649103 | 0.77 | BCHE (0.43) | LMNAALDH1A1NPC1PKMRAB9A | |
| SCHEMBL30346306 | 0.77 | BCHE (0.43) | LMNAALDH1A1NPC1PKMRAB9A | |
| SCHEMBL31736935 | 0.76 | PTGDR2 (0.52) | PTGDR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4114235 | 0.76 | PTGDR2 (0.52) | PTGDR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5408332 | 0.75 | LMNA (0.45) | LMNAALDH1A1PTGDR2SLC22A12MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197587-A1 | Quinoline Derivatives as CRTH2 Antagonists | PFIZER INC | 2007-08-23 | — | — | US | disclosed |
| US-7220760-B2 | Quinoline derivatives as CRTH2 antagonists | PFIZER INC. (US) | 2007-05-22 | — | — | US | disclosed |
| EP-1556356-B1 | TETRAHYDROQUINOLINE DERIVATIVES AS CRTH2 ANTAGONISTS | WARNER LAMBERT CO (US) | 2006-05-31 | — | — | EP | disclosed |
| EP-1556356-A1 | TETRAHYDROQUINOLINE DERIVATIVES AS CRTH2 ANTAGONISTS | Warner-Lambert Company LLC (US) | 2005-07-27 | — | — | EP | disclosed |
| US-20040132772-A1 | 1-carbonyl-4-carbonylaminotetrahydroquinoline derivatives; especially treating asthma and allergic rhinitis | WARNER-LAMBERT COMPANY LLC | 2004-07-08 | — | — | US | disclosed |
| EP-1435356-A1 | Quinoline derivatives as CRTH2 antagonists | Warner-Lambert Company LLC (US) | 2004-07-07 | — | — | EP | disclosed |
| WO-2004035543-A1 | TETRAHYDROQUINOLINE DERIVATIVES AS CRTH2 ANTAGONISTS | WARNER-LAMBERT COMPANY LLC (US) | 2004-04-29 | — | — | WO | disclosed |
| EP-1413306-A1 | Tetrahydroquinoline derivatives as CRTH2 antagonists | Warner-Lambert Company LLC (US) | 2004-04-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132772-A1 | 1-carbonyl-4-carbonylaminotetrahydroquinoline derivatives; especially treating asthma and allergic rhinitis | HRH1, HRH2, HRH4 | LMNA 2805/4885ALDH1A1 99/4885PTGDR2 748/4885 |
| US-20070197587-A1 | Quinoline Derivatives as CRTH2 Antagonists | HRH2, HRH1, HRH3 | LMNA 3648/4885ALDH1A1 1391/4885PTGDR2 120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.