Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 2/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5411056 | 0.89 | — | — | |
| SCHEMBL5404342 | 0.88 | PDE1A (0.38) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL5395357 | 0.86 | PDE5A (0.39) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL5411081 | 0.86 | SMN1; SMN2 (0.41) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL5400678 | 0.86 | SLC16A1 (0.52) | PDE5APDE3BPDE3A | |
| SCHEMBL5398848 | 0.84 | PDE1A (0.37) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL5400117 | 0.83 | CMA1 (0.37) | PDE1APDE1BPDE1C | |
| SCHEMBL5409602 | 0.83 | PDE1A (0.38) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL5398349 | 0.83 | PDE1A (0.37) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL5406059 | 0.82 | SLC16A1 (0.39) | PDE5APDE3BPDE3APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285558-B2 | Pyrazolo[3,4-d]pyrimidines inhibiting H. pylori infections | ASTRAZENECA AB (SE) | 2007-10-23 | — | — | US | disclosed |
| US-7285558-B2 | Pyrazolo[3,4-d]pyrimidines inhibiting H. pylori infections | ASTRAZENECA AB (SE) | 2007-10-23 | — | — | US | disclosed |
| US-7285558-B2 | Pyrazolo[3,4-d]pyrimidines inhibiting H. pylori infections | ASTRAZENECA AB (SE) | 2007-10-23 | — | — | US | disclosed |