Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 5/20 | 0.45 |
| ▸ | CHUK | O15111 | 4/20 | 0.45 |
| ▸ | TTK | P33981 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 5/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ATP1A1 | P05023 | 3/20 | 0.38 |
| ▸ | ATP1B1 | P05026 | 3/20 | 0.38 |
| ▸ | ATP1A3 | P13637 | 3/20 | 0.38 |
| ▸ | ATP1B2 | P14415 | 3/20 | 0.38 |
| ▸ | ATP1A2 | P50993 | 3/20 | 0.38 |
| ▸ | ATP1B3 | P54709 | 3/20 | 0.38 |
| ▸ | FXYD2 | P54710 | 3/20 | 0.38 |
| ▸ | ATP1A4 | Q13733 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5396816 | 0.83 | FYN (0.48) | TTKCYP1A2CYP3A4CYP2D6SRC | |
| SCHEMBL2816677 | 0.81 | HTR2C (0.51) | IKBKBCHUKLCK | |
| SCHEMBL5403440 | 0.78 | FLT3 (0.59) | TTKFLT3 | |
| SCHEMBL5405124 | 0.78 | FLT3 (0.52) | IKBKBTTKSRCLCKFLT3 | |
| SCHEMBL5404865 | 0.75 | FLT3 (0.56) | TTKFLT3 | |
| SCHEMBL15940871 | 0.72 | CYP1A2 (0.44) | CYP1A2CYP3A4CYP2D6SRCLCK | |
| SCHEMBL2815052 | 0.70 | HTR2C (0.47) | IKBKBCHUKLCKGAA | |
| SCHEMBL2818724 | 0.70 | IKBKB (0.48) | IKBKBCHUKLCKEGFR | |
| SCHEMBL2818464 | 0.70 | HTR2C (0.47) | IKBKBCHUKSRCLCKGAA | |
| SCHEMBL2816389 | 0.70 | HTR2C (0.47) | IKBKBCHUKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009832-A1 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN, INC. | 2005-01-13 | — | — | US | claimed |
| US-20040220189-A1 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhbitors | SUGEN, INC. | 2004-11-04 | — | — | US | claimed |
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-7157460-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-7157460-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-20050009832-A1 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN, INC. | 2005-01-13 | — | — | US | disclosed |
| US-20040220189-A1 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhbitors | SUGEN, INC. | 2004-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009832-A1 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | MAP3K8, MAP3K2, MAP3K5 | IKBKB 452/4885CHUK 237/4885TTK 69/4885 |
| US-20040220189-A1 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhbitors | MAP3K8, MAP4K4, MAP3K2 | IKBKB 337/4885CHUK 100/4885TTK 369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.