Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 11/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 9/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5420660 | 1.00 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL5409334 | 1.00 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL5398178 | 1.00 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL14519303 | 1.00 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL5398172 | 1.00 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL5407616 | 1.00 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL5419455 | 1.00 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL5404385 | 1.00 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL5404392 | 1.00 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL5401462 | 1.00 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1429811-A4 | THEURAPEUTIC TROPANE COMPOUNDS | HARVARD COLLEGE (US) | 2006-05-17 | — | — | EP | claimed |
| EP-1429811-A1 | THEURAPEUTIC TROPANE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2004-06-23 | — | — | EP | claimed |
| US-20030125352-A1 | Therapeutic tropane compounds | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2003-07-03 | — | — | US | claimed |
| US-20030105125-A1 | Tropane analogs and methods for inhibition of monoamine transport | WILMINGTON TRUST (LONDON) LIMITED, AS SECURITY AGENT (GB) | 2003-06-05 | — | — | US | claimed |
| WO-2003015830-A1 | THEURAPEUTIC TROPANE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2003-02-27 | — | — | WO | claimed |
| US-20070244149-A1 | Tropane analogs and methods for inhibition of monoamine transport | ORGANIX, INC. (US) | 2007-10-18 | — | — | US | disclosed |
| US-7199132-B2 | Tropane analogs and methods for inhibition of monoamine transport | ORGANIX, INC. (US) | 2007-04-03 | — | — | US | disclosed |
| EP-1429811-A4 | THEURAPEUTIC TROPANE COMPOUNDS | HARVARD COLLEGE (US) | 2006-05-17 | — | — | EP | disclosed |
| EP-1429811-A1 | THEURAPEUTIC TROPANE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2004-06-23 | — | — | EP | disclosed |
| US-20030125352-A1 | Therapeutic tropane compounds | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2003-07-03 | — | — | US | disclosed |
| US-20030105125-A1 | Tropane analogs and methods for inhibition of monoamine transport | WILMINGTON TRUST (LONDON) LIMITED, AS SECURITY AGENT (GB) | 2003-06-05 | — | — | US | disclosed |
| WO-2003015830-A1 | THEURAPEUTIC TROPANE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2003-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105125-A1 | Tropane analogs and methods for inhibition of monoamine transport | SLC6A2, SLC6A4, SLC6A3 | SLC6A3 3/4885SLC6A4 2/4885SLC6A2 1/4885 |
| US-20030125352-A1 | Therapeutic tropane compounds | HTT, GAP43, MAPT | SLC6A3 23/4885SLC6A4 83/4885SLC6A2 9/4885 |
| US-20070244149-A1 | Tropane analogs and methods for inhibition of monoamine transport | SLC6A2, SLC6A4, SLC6A3 | SLC6A3 3/4885SLC6A4 2/4885SLC6A2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.