Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 18/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699084 | 0.82 | GRM5 (0.61) | GRM5 | |
| SCHEMBL4698694 | 0.80 | GRM5 (0.59) | GRM5 | |
| SCHEMBL13684148 | 0.80 | GRM5 (0.59) | GRM5 | |
| SCHEMBL4700513 | 0.79 | GRM5 (0.60) | GRM5 | |
| SCHEMBL4699647 | 0.79 | GRM5 (0.53) | GRM5 | |
| SCHEMBL4703270 | 0.79 | GRM5 (0.53) | GRM5 | |
| SCHEMBL13683864 | 0.77 | GRM5 (0.69) | GRM5 | |
| SCHEMBL4702694 | 0.77 | GRM5 (0.65) | GRM5 | |
| SCHEMBL6694200 | 0.77 | GRM5 (0.60) | GRM5 | |
| SCHEMBL4703283 | 0.77 | GRM5 (0.52) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253190-B2 | Heteroaryl substituted tetrazole modulators of metabotrophic glutamate receptor-5 | MERCK & CO., INC. (US) | 2007-08-07 | — | — | US | claimed |