Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4054102 | 0.86 | PDE4B (0.43) | PDE4BADORA1TP53 | |
| SCHEMBL5750555 | 0.81 | PDE4B (0.43) | PDE4BACHEBACE1TP53MAPT | |
| SCHEMBL4057070 | 0.78 | TP53 (0.47) | PDE4BACHEBACE1PARP1ADORA2A | |
| SCHEMBL4052347 | 0.77 | PDE4B (0.44) | PDE4BADORA2AADORA2BADORA1MAPT | |
| SCHEMBL4055425 | 0.73 | PDE4B (0.48) | PDE4BADORA1TP53MAPT | |
| SCHEMBL4053904 | 0.73 | PARP1 (0.44) | PDE4BACHEBACE1PARP1ADORA1 | |
| SCHEMBL4051327 | 0.72 | KCNJ6 (0.46) | PDE4BADORA2AADORA2BADORA1TP53 | |
| SCHEMBL4054075 | 0.72 | ACP1 (0.50) | PDE4BADORA2AADORA2BADORA1MAPT | |
| SCHEMBL4051904 | 0.71 | ACHE (0.43) | PDE4BACHEBACE1PARP1ADORA1 | |
| SCHEMBL4057455 | 0.71 | ABCG2 (0.52) | PDE4BADORA2AADORA2BADORA1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007510689-A | — | — | 2007-04-26 | — | — | JP | claimed |
| EP-1682519-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2006-07-26 | — | — | EP | claimed |
| WO-2005049581-A1 | PYRIDAZIN-3 (2H) -ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA, S.A. (ES) | 2005-06-02 | — | — | WO | claimed |