Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5984586 | 0.93 | HTR3A (0.54) | HTR3ASMN1; SMN2CHRNA7TP53 | |
| SCHEMBL5415044 | 0.87 | HTR3A (0.48) | HTR3ARAB9ACHRNA7 | |
| SCHEMBL1963490 | 0.85 | HTR3A (0.49) | HTR3ANPC1SMN1; SMN2RAB9ACHRNA7 | |
| SCHEMBL12044747 | 0.85 | HTR3A (0.49) | HTR3ANPC1SMN1; SMN2RAB9ACHRNA7 | |
| SCHEMBL5402371 | 0.85 | HTR3A (0.42) | HTR3ANPC1RAB9ACHRNA7MAPT | |
| SCHEMBL5984302 | 0.84 | HTR3A (0.54) | HTR3ANPC1RAB9ACHRNA7MAPT | |
| SCHEMBL5402828 | 0.84 | CHRNA7 (0.57) | HTR3ACHRNA7 | |
| SCHEMBL5411054 | 0.82 | CHRNA7 (0.48) | HTR3ACHRNA7 | |
| SCHEMBL5399267 | 0.80 | HTR3A (0.49) | HTR3ACHRNA7 | |
| SCHEMBL5407219 | 0.79 | CHRNA7 (0.42) | HTR3ACHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007530590-A | — | — | 2007-11-01 | — | — | JP | claimed |
| EP-1735306-A2 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, AND PREPARATION AND USES THEREOF | Memory Pharmaceuticals Corporation (US) | 2006-12-27 | — | — | EP | claimed |
| WO-2005092890-A2 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | claimed |
| EP-1735306-A2 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, AND PREPARATION AND USES THEREOF | Memory Pharmaceuticals Corporation (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005092890-A2 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |