Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | PTPRC | P08575 | 1/20 | 0.44 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4896464 | 1.00 | ALDH1A1 (0.51) | ALDH1A1SLC15A1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL4896468 | 0.90 | ALDH1A1 (0.51) | ALDH1A1SLC15A1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL5405061 | 0.90 | ALDH1A1 (0.51) | ALDH1A1SLC15A1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL8201762 | 0.87 | ALDH1A1 (0.55) | ALDH1A1SLC15A1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL15114666 | 0.85 | ALDH1A1 (0.53) | ALDH1A1SLC15A1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL20564964 | 0.84 | ALDH1A1 (0.51) | ALDH1A1SLC15A1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL27387256 | 0.83 | ALDH1A1 (0.50) | ALDH1A1SLC15A1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL15105964 | 0.82 | ALDH1A1 (0.53) | ALDH1A1KMT2AMAPK1L3MBTL1SLC6A2 | |
| SCHEMBL27408279 | 0.81 | ALDH1A1 (0.51) | ALDH1A1SLC15A1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL20111501 | 0.80 | ALDH1A1 (0.55) | ALDH1A1SLC15A1KMT2AMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199158-B2 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2007-04-03 | — | — | US | disclosed |
| US-7199158-B2 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2007-04-03 | — | — | US | disclosed |
| US-7199158-B2 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2007-04-03 | — | — | US | disclosed |
| US-7038084-B2 | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2006-05-02 | — | — | US | disclosed |
| US-20060020009-A1 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2006-01-26 | — | — | US | disclosed |
| US-20060020009-A1 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2006-01-26 | — | — | US | disclosed |
| US-20060020009-A1 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2006-01-26 | — | — | US | disclosed |
| US-6951886-B2 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 2005-10-04 | — | — | US | disclosed |
| US-20050004043-A1 | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2005-01-06 | — | — | US | disclosed |
| US-6727282-B2 | HUMAN IMMUNODEFICIENCY VIRUS (HIV) OR AIDS TREATMENT | G.D. SEARLE & CO. | 2004-04-27 | — | — | US | disclosed |
| EP-0656886-B1 | N-(ALKANOYLAMINO-2-HYDROXYPROPYL)-SULFONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS | SEARLE & CO (US) | 1997-06-25 | — | — | EP | disclosed |
| US-5610190-A | Retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 1997-03-11 | — | — | US | disclosed |
| US-5602119-A | TREATMENT OF HIV AND AIDS | G. D. SEARLE & CO. | 1997-02-11 | — | — | US | disclosed |
| EP-0666841-B1 | SUCCINOYLAMINO HYDROXYETHYLAMINO SULFAMIC ACID DERIVATIVES USEFUL AS RETROVIRAL PROTEASE INHIBITORS | SEARLE & CO (US) | 1997-01-22 | — | — | EP | disclosed |
| US-5510349-A | HUMAN IMMUNODEFICIENCY VIRUS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5482947-A | ENZYME INHIBITORS FOR HIV PROTEASE INHIBITION FROM UREA OR THIOUREA COMPOUNDS | TALLEY JOHN J (US) | 1996-01-09 | — | — | US | disclosed |
| US-5463104-A | Treating human immunodeficiency virus infection | G. D. SEARLE & CO. (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0656886-A1 | N-(ALKANOYLAMINO-2-HYDROXYPROPYL)-SULFONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS. | SEARLE & CO (US) | 1995-06-14 | — | — | EP | disclosed |
| WO-1994004491-A1 | N-(ALKANOYLAMINO-2-HYDROXYPROPYL)-SULFONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1994-03-03 | — | — | WO | disclosed |
| WO-1993023368-A1 | UREA-CONTAINING HYDROXYETHYLAMINE COMPOUNDS AS RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1993-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060020009-A1 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors | HAT1, UBXN4, PRSS1 | ALDH1A1 3181/4885SLC15A1 1464/4885KMT2A 1060/4885 |
| US-20050004043-A1 | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | PRSS1, DNPEP, PREP | ALDH1A1 2155/4885SLC15A1 1284/4885KMT2A 603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.