Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 9/20 | 0.56 |
| ▸ | ACHE | P22303 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5405915 | 1.00 | BCHE (0.56) | BCHEACHEKDM4ELMNAMAPT | |
| SCHEMBL6605118 | 0.85 | BCHE (0.61) | BCHEACHEABCG2HRH3CYP1A1 | |
| SCHEMBL6605111 | 0.85 | BCHE (0.61) | BCHEACHEABCG2HRH3CYP1A1 | |
| SCHEMBL5413823 | 0.85 | F3 (0.56) | LMNAMAPTABCG2CYP1A1CYP1B1 | |
| SCHEMBL5413825 | 0.85 | F3 (0.56) | LMNAMAPTABCG2CYP1A1CYP1B1 | |
| SCHEMBL5414954 | 0.75 | ABCG2 (0.38) | LMNAMAPTABCG2CYP1A1CYP1B1 | |
| SCHEMBL5414956 | 0.75 | ABCG2 (0.38) | LMNAMAPTABCG2CYP1A1CYP1B1 | |
| SCHEMBL5414962 | 0.75 | ABCG2 (0.38) | LMNAMAPTABCG2CYP1A1CYP1B1 | |
| SCHEMBL25191376 | 0.74 | BCHE (0.83) | BCHEACHEABCG2MAOB | |
| SCHEMBL25279110 | 0.74 | BCHE (0.83) | BCHEACHEABCG2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297694-B2 | Pyridylfurans and pyrroles as Raf kinase inhibitors | SMITHKLINE BEECHUM P.L.C. (GB) | 2007-11-20 | — | — | US | disclosed |
| US-20040254186-A1 | Pyridylfurans and pyrroles as raf kinase inhibitors | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254186-A1 | Pyridylfurans and pyrroles as raf kinase inhibitors | BRAF, ARAF, RAF1 | BCHE 4032/4885ACHE 1282/4885KDM4E 1466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.