Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F3 | P13726 | 2/20 | 0.56 |
| ▸ | TNFRSF1A | P19438 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 7/20 | 0.53 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | MAOA | P21397 | 3/20 | 0.52 |
| ▸ | XDH | P47989 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | P4HB | P07237 | 1/20 | 0.52 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5413823 | 1.00 | F3 (0.56) | F3TNFRSF1ACYP3A4MAOBCXCL12 | |
| SCHEMBL5405919 | 0.85 | BCHE (0.56) | CYP3A4MAOBMAPTABCG2LMNA | |
| SCHEMBL5405915 | 0.85 | BCHE (0.56) | CYP3A4MAOBMAPTABCG2LMNA | |
| SCHEMBL5414956 | 0.80 | ABCG2 (0.38) | CYP3A4MAOBMAPTMAOAMEN1 | |
| SCHEMBL5414954 | 0.80 | ABCG2 (0.38) | CYP3A4MAOBMAPTMAOAMEN1 | |
| SCHEMBL5414962 | 0.80 | ABCG2 (0.38) | CYP3A4MAOBMAPTMAOAMEN1 | |
| SCHEMBL5408887 | 0.79 | GPR119 (0.45) | MAPTALDH1A1LMNA | |
| 4,4'-Dimethoxychalcone SCHEMBL978243 | 0.75 | F3 (1.00) | F3TNFRSF1ACYP3A4MAOBMAPT | |
| 4,4'-Dimethoxychalcone SCHEMBL978242 | 0.75 | F3 (1.00) | F3TNFRSF1ACYP3A4MAOBMAPT | |
| SCHEMBL24844 | 0.74 | ALDH1A1 (0.39) | MAOBMAPTRAB9AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297694-B2 | Pyridylfurans and pyrroles as Raf kinase inhibitors | SMITHKLINE BEECHUM P.L.C. (GB) | 2007-11-20 | — | — | US | disclosed |
| US-20040254186-A1 | Pyridylfurans and pyrroles as raf kinase inhibitors | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254186-A1 | Pyridylfurans and pyrroles as raf kinase inhibitors | BRAF, ARAF, RAF1 | F3 865/4885TNFRSF1A 1144/4885CYP3A4 3513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.