Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | LIG1 | P18858 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24366501 | 1.00 | PRCP (0.42) | PRCPTDP1MAPTGSK3BBACE1 | |
| SCHEMBL2708297 | 1.00 | PRCP (0.42) | PRCPTDP1MAPTGSK3BBACE1 | |
| Hydrochloric Acid SCHEMBL3717615 | 0.98 | PRCP (0.41) | PRCPTDP1MAPTGSK3BBACE1 | |
| SCHEMBL2707254 | 0.81 | PRCP (0.47) | PRCPMAPTLMNAKDM1ATP53 | |
| SCHEMBL29330477 | 0.81 | PRCP (0.47) | PRCPMAPTLMNAKDM1ATP53 | |
| SCHEMBL2708172 | 0.81 | KDM1A (0.38) | KDM1AMAPK1ALDH1A1MAOB | |
| SCHEMBL29330391 | 0.81 | KDM1A (0.38) | KDM1AMAPK1ALDH1A1MAOB | |
| SCHEMBL2705783 | 0.80 | KDM4E (0.42) | TDP1GSK3BMAPK1ALDH1A1CA1 | |
| Hydrochloric Acid SCHEMBL29116032 | 0.80 | PRCP (0.46) | PRCPMAPTLMNATP53GAA | |
| Hydrochloric Acid SCHEMBL29116034 | 0.80 | PRCP (0.46) | PRCPMAPTLMNATP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135414-A1 | Tachykinin Antagonists | ALVARO GUISEPPE | 2007-06-14 | — | — | US | disclosed |
| US-7196077-B2 | Tachykinin antagonists | GLAXO GROUP LIMITED (GB) | 2007-03-27 | — | — | US | disclosed |
| EP-1377558-B1 | [1,4]-DIAZEPANE-1-CARBOXYLIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS TACHYKININ ANTAGONISTS | GLAXO GROUP LTD (GB) | 2005-08-17 | — | — | EP | disclosed |
| US-20040127485-A1 | 1,4! - diazepane -1- carboxylic acid derivatives process for their preparation and their use as tachykinin antagonists | GLAXO GROUP LIMITED (GB) | 2004-07-01 | — | — | US | disclosed |
| EP-1377558-A1 | [1,4]-DIAZEPANE-1-CARBOXYLIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS TACHYKININ ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002081457-A1 | `1,4!-DIAZEPANE-1-CARBOXYLIC ACID DERIVATIVES PROCESS FOR THEIR PREPARATION AND THEIR USE AS TACHYKININ ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2002-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127485-A1 | 1,4! - diazepane -1- carboxylic acid derivatives process for their preparation and their use as tachykinin antagonists | NPY1R, CRHR1, GRIN1 | PRCP 2223/4885TDP1 4260/4885MAPT 3460/4885 |
| US-20070135414-A1 | Tachykinin Antagonists | NPSR1, TACR2, NPY4R | PRCP 2539/4885TDP1 4706/4885MAPT 3854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.