Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5402496 | 0.86 | POLB (0.37) | ALDH1A1RAB9ANPC1ENPP3ALPL | |
| SCHEMBL5410158 | 0.78 | ALDH1A1 (0.39) | ALDH1A1LMNAKDM4ESRD5A2RAB9A | |
| SCHEMBL5406467 | 0.77 | ALDH1A1 (0.40) | ALDH1A1KDM4ERAB9ANPC1HTT | |
| SCHEMBL5417624 | 0.76 | ALDH1A1 (0.37) | ALDH1A1LMNAKDM4ESRD5A2RAB9A | |
| SCHEMBL5417410 | 0.68 | ALDH1A1 (0.37) | ALDH1A1KDM4ERAB9ANPC1KMT2A | |
| SCHEMBL5408337 | 0.67 | AKT1 (0.32) | ALDH1A1KDM4ERAB9ANPC1POLB | |
| SCHEMBL29139301 | 0.62 | ALDH1A1 (0.50) | ALDH1A1LMNAKDM4ESRD5A2RAB9A | |
| SCHEMBL822185 | 0.60 | ALDH1A1 (1.00) | ALDH1A1LMNASRD5A2RAB9AHTT | |
| SCHEMBL52200 | 0.60 | ALDH1A1 (1.00) | ALDH1A1LMNASRD5A2RAB9AHTT | |
| SCHEMBL4683800 | 0.59 | ALDH1A1 (0.50) | ALDH1A1LMNAKDM4ESRD5A2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362049-B1 | PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES | OREAL (FR) | 2006-06-21 | — | — | EP | claimed |
| US-20040088801-A1 | Novel pyrazolo-triazoles and use of said compounds for dyeing keratinous fibres | L'OREAL S.A. (FR) | 2004-05-13 | — | — | US | claimed |
| EP-1362049-A1 | NOVEL PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES | L'OREAL (FR) | 2003-11-19 | — | — | EP | claimed |
| WO-2002064596-A1 | NOVEL PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES | L'OREAL (FR) | 2002-08-22 | — | — | WO | claimed |
| US-7192452-B2 | Pyrazolo-triazoles and use of said compounds for dyeing keratinous fibres | L'OREAL S.A. (FR) | 2007-03-20 | — | — | US | disclosed |
| EP-1362049-B1 | PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES | OREAL (FR) | 2006-06-21 | — | — | EP | disclosed |
| US-20040088801-A1 | Novel pyrazolo-triazoles and use of said compounds for dyeing keratinous fibres | L'OREAL S.A. (FR) | 2004-05-13 | — | — | US | disclosed |
| EP-1362049-A1 | NOVEL PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES | L'OREAL (FR) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002064596-A1 | NOVEL PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES | L'OREAL (FR) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040088801-A1 | Novel pyrazolo-triazoles and use of said compounds for dyeing keratinous fibres | KRT18, CYC1, CBR3 | ALDH1A1 180/4885LMNA 1263/4885KDM4E 1593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.