Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.49 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.48 |
| ▸ | SMC2 | O95347 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.48 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.48 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14499996 | 0.93 | MAP2K1 (0.48) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL13842002 | 0.93 | MAP2K1 (0.50) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL3974326 | 0.90 | MAP2K1 (0.49) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL13841975 | 0.84 | MAP2K1 (0.57) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL5412500 | 0.83 | MAP2K1 (0.59) | MAP2K1MAP2K2CSNK2A2ABCB11NQO2 | |
| SCHEMBL3973358 | 0.83 | MAP2K1 (0.53) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL5401946 | 0.81 | MAP2K1 (0.49) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL15088158 | 0.80 | MEN1 (0.44) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL5331353 | 0.79 | POLB (0.39) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL3973143 | 0.79 | MAP2K1 (0.47) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230099-B2 | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA, INC. (US) | 2007-06-12 | — | — | US | claimed |
| EP-1673339-B1 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2013-07-03 | — | — | EP | disclosed |