⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11081460 | 0.78 | — | — | |
| SCHEMBL2424898 | 0.78 | — | — | |
| SCHEMBL401494 | 0.78 | — | — | |
| SCHEMBL2866356 | 0.74 | — | — | |
| SCHEMBL8199466 | 0.74 | USP2 (0.33) | — | |
| SCHEMBL18576168 | 0.71 | KDM4E (0.30) | — | |
| SCHEMBL24450286 | 0.70 | — | — | |
| SCHEMBL14363844 | 0.70 | — | — | |
| SCHEMBL17578910 | 0.70 | — | — | |
| SCHEMBL7486852 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202235-B2 | Tetracycline compounds for treatment of cryptosporidium parvum related disorders | TRUSTEES OF TUFTS COLLEGE (US) | 2007-04-10 | — | — | US | claimed |
| US-20050215532-A1 | Tetracycline compounds for treatment of cryptosporidium parvum related disorders | TRUSTEES OF TUFTS COLLEGE (US) | 2005-09-29 | — | — | US | claimed |
| EP-1263442-A1 | TETRACYCLINE COMPOUNDS FOR TREATMENT OF i CRYPTOSPORIDIUM PARVUM /i RELATED DISORDERS | TRUSTEES OF TUFTS COLLEGE (US) | 2002-12-11 | — | — | EP | claimed |
| US-20020115644-A1 | Tetracycline compounds for treatment of Cryptosporidium parvum related disorders | PARATEK PHARMACEUTICALS, INC. | 2002-08-22 | — | — | US | claimed |
| WO-2001052858-A1 | TETRACYCLINE COMPOUNDS FOR TREATMENT OF CRYPTOSPORIDIUM PARVUM RELATED DISORDERS | TRUSTEES OF TUFTS COLLEGE (US) | 2001-07-26 | — | — | WO | claimed |