Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 11/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31672445 | 0.86 | KDR (0.44) | PAK1KDR | |
| SCHEMBL10151156 | 0.86 | KDR (0.44) | PAK1KDR | |
| SCHEMBL5483339 | 0.85 | GRM4 (0.40) | PAK1KDRSYKGRM4 | |
| SCHEMBL2877133 | 0.76 | KDR (0.46) | PAK1KDR | |
| SCHEMBL31672441 | 0.76 | KDR (0.46) | PAK1KDR | |
| SCHEMBL6098675 | 0.75 | BTK (0.39) | PAK1KDRSYKGRM4 | |
| SCHEMBL31672487 | 0.68 | KDR (0.46) | KDR | |
| SCHEMBL10151171 | 0.68 | KDR (0.46) | KDR | |
| SCHEMBL2867774 | 0.68 | PAK1 (0.42) | PAK1KDRSYK | |
| SCHEMBL31672454 | 0.68 | PAK1 (0.42) | PAK1KDRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262203-B2 | Pyrimidineamines as angiogenesis modulators | SMITHKLINE BEECHAM CORPORATION (US) | 2007-08-28 | — | — | US | claimed |