Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | POLB | P06746 | 4/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | PKM | P14618 | 2/20 | 0.71 |
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1974783 | 0.92 | ALDH1A1 (0.85) | ALDH1A1GAAPOLBMEN1KMT2A | |
| SCHEMBL6805741 | 0.88 | ALDH1A1 (0.81) | ALDH1A1GAAPOLBTSHRSMN1; SMN2 | |
| SCHEMBL1988224 | 0.88 | ALDH1A1 (0.81) | ALDH1A1GAAPOLBTSHRSMN1; SMN2 | |
| SCHEMBL10445162 | 0.86 | ALDH1A1 (0.85) | ALDH1A1GAAPOLBMEN1KMT2A | |
| SCHEMBL1902263 | 0.86 | ALDH1A1 (0.85) | ALDH1A1GAAPOLBMEN1KMT2A | |
| SCHEMBL31681326 | 0.85 | ALDH1A1 (0.73) | ALDH1A1GAAPOLBMEN1KMT2A | |
| SCHEMBL12939706 | 0.85 | ALDH1A1 (0.73) | ALDH1A1GAAPOLBMEN1KMT2A | |
| SCHEMBL12626008 | 0.84 | GAA (0.72) | ALDH1A1GAAPOLBMEN1KMT2A | |
| SCHEMBL4225535 | 0.84 | ALDH1A1 (0.72) | ALDH1A1GAAPOLBMEN1KMT2A | |
| SCHEMBL13202848 | 0.84 | SMN1; SMN2 (1.00) | ALDH1A1GAAPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189756-B2 | Pyrrolidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2007-03-13 | — | — | US | disclosed |