Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.53 |
| ▸ | LSS | P48449 | 1/20 | 0.47 |
| ▸ | NTMT1 | Q9BV86 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.39 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5396665 | 0.89 | CHRNA7 (0.64) | CHRNA7LSSNTMT1CYP1A2CYP2D6 | |
| SCHEMBL13444725 | 0.82 | CHRNA7 (0.71) | CHRNA7LSSCYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL5431557 | 0.81 | CHRNA7 (0.53) | CHRNA7LSSNTMT1CYP1A2CYP2D6 | |
| SCHEMBL5402646 | 0.80 | CHRNA7 (0.49) | CHRNA7LSSCHRM2CHRM1CHRM3 | |
| Trifluoroacetic Acid SCHEMBL5412775 | 0.80 | LSS (0.44) | CHRNA7LSSCYP2D6CHRM2CHRM1 | |
| Fumaric Acid SCHEMBL5420562 | 0.79 | CHRNA7 (0.50) | CHRNA7LSSCYP2D6CHRM2CHRM1 | |
| Fumaric Acid SCHEMBL5420571 | 0.79 | CHRNA7 (0.50) | CHRNA7LSSCYP2D6CHRM2CHRM1 | |
| SCHEMBL3229549 | 0.79 | CHRNA7 (0.68) | CHRNA7LSSCYP1A2CYP2D6CHRM1 | |
| SCHEMBL3229552 | 0.79 | CHRNA7 (0.68) | CHRNA7LSSCYP1A2CYP2D6CHRM1 | |
| Trifluoroacetic Acid SCHEMBL1542298 | 0.77 | PRKAG1 (0.43) | CHRNA7LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309699-B2 | 3-Quinuclidinyl amino-substituted biaryl derivatives | ABBOTT LABORATORIES (US) | 2007-12-18 | — | — | US | disclosed |
| US-20070275975-A1 | 3-QUINUCLIDINYL AMINO-SUBSTITUTED BIARYL DERIVATIVES | JI JIANGUO | 2007-11-29 | — | — | US | disclosed |
| US-20050159597-A1 | 3-Quinuclidinyl amino-substituted biaryl derivatives | ABBOTT LABORATORIES | 2005-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159597-A1 | 3-Quinuclidinyl amino-substituted biaryl derivatives | CHRNA7, CHRNA9, CHRNA1 | CHRNA7 1/4885LSS 2291/4885NTMT1 1622/4885 |
| US-20070275975-A1 | 3-QUINUCLIDINYL AMINO-SUBSTITUTED BIARYL DERIVATIVES | CHRNA7, CHRNA9, CHRNA1 | CHRNA7 1/4885LSS 2291/4885NTMT1 1622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.