Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PLG | P00747 | 2/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2333756 | 1.00 | POLB (0.54) | POLBPLGGBA1MEN1KMT2A | |
| SCHEMBL1176855 | 1.00 | POLB (0.54) | POLBPLGGBA1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL17700584 | 0.98 | POLB (0.53) | POLBPLGGBA1MEN1KMT2A | |
| SCHEMBL23459229 | 0.90 | POLB (0.60) | POLBPLGGBA1 | |
| SCHEMBL23459230 | 0.90 | POLB (0.60) | POLBPLGGBA1 | |
| SCHEMBL28161970 | 0.84 | POLB (0.40) | POLBPLGGBA1MEN1KMT2A | |
| SCHEMBL18577123 | 0.83 | MALT1 (0.41) | POLB | |
| SCHEMBL29197761 | 0.83 | KDM1A (0.39) | POLB | |
| SCHEMBL1177083 | 0.83 | MALT1 (0.41) | POLB | |
| SCHEMBL31302116 | 0.83 | CYP19A1 (0.38) | POLBOPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020158762-A1 | HETEROCYCLIC COMPOUND | 武田薬品工業株式会社 | 2020-08-06 | — | — | WO | disclosed |
| WO-2013007371-A2 | KINETIC RESOLUTION OF CHIRAL AMINES | ETH ZURICH (CH) | 2013-01-17 | — | — | WO | disclosed |
| US-7253172-B2 | Dipeptidyl peptidase inhibitors for the treatment of diabetes | MERCK & CO., INC. (US) | 2007-08-07 | — | — | US | disclosed |
| EP-1406622-B1 | DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES | MERCK & CO INC (US) | 2006-02-22 | — | — | EP | disclosed |
| EP-1406622-A4 | DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES | MERCK & CO INC (US) | 2005-01-19 | — | — | EP | disclosed |
| US-20040236102-A1 | Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK SHARP & DOHME CORP. | 2004-11-25 | — | — | US | disclosed |
| EP-1406622-A2 | DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES | Merck & Co., Inc. (US) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003000181-A2 | DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES | MERCK & CO., INC. (US) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040236102-A1 | Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | DPP4, DPP3, DPP7 | POLB 3148/4885PLG 301/4885GBA1 760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.