Sugi Predict

Sugi Predict / Compounds / SCHEMBL2333756

SCHEMBL2333756

SCHEMBL2333756

c1ccc(CC2COCCN2)cc1

nearest known ligand 0.56

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.54
▸ PLG P00747 2/20 0.42
▸ GBA1 P04062 1/20 0.42
▸ MEN1 O00255 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ SLC22A1 O15245 1/20 0.39
▸ PRCP P42785 1/20 0.39
▸ OPRM1 P35372 1/20 0.38
▸ OPRD1 P41143 1/20 0.38
▸ OPRK1 P41145 1/20 0.38
▸ OPRL1 P41146 1/20 0.38
▸ OGFRL1 Q5TC84 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1176855 1.00 POLB (0.54) POLBPLGGBA1MEN1KMT2A
SCHEMBL5408210 1.00 POLB (0.54) POLBPLGGBA1MEN1KMT2A
Hydrochloric Acid SCHEMBL17700584 0.98 POLB (0.53) POLBPLGGBA1MEN1KMT2A
SCHEMBL23459229 0.90 POLB (0.60) POLBPLGGBA1
SCHEMBL23459230 0.90 POLB (0.60) POLBPLGGBA1
SCHEMBL28161970 0.84 POLB (0.40) POLBPLGGBA1MEN1KMT2A
SCHEMBL18577123 0.83 MALT1 (0.41) POLB
SCHEMBL29197761 0.83 KDM1A (0.39) POLB
SCHEMBL1177083 0.83 MALT1 (0.41) POLB
SCHEMBL31302116 0.83 CYP19A1 (0.38) POLBOPRM1OPRD1OPRK1OPRL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4069366-B1 ATM KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF CHDI FOUNDATION INC (US) 2025-03-19 — — EP disclosed
US-20240368127-A1 HSD17B13 INHIBITORS AND USES THEREOF FL2022-001, INC. 2024-11-07 — — US disclosed
US-20240067631-A1 PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS CYTOKINETICS, INC. 2024-02-29 — — US disclosed
US-11685734-B2 ATM kinase inhibitors and compositions and methods of use thereof CHDI FOUNDATION, INC. (US) 2023-06-27 — — US disclosed
WO-2023043836-A1 HSD17B13 INHIBITORS AND USES THEREOF METACRINE, INC. (US) 2023-03-23 — — WO disclosed
US-20210188827-A1 ATM KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF CHDI FOUNDATION, INC. 2021-06-24 — — US disclosed
EP-2800738-B1 HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR USE NOVARTIS AG (CH) 2020-04-08 — — EP disclosed
CN-107011229-B The application method of heterocyclic compound and they 诺华股份有限公司 2019-11-05 — — CN disclosed
US-10370388-B2 Heterocyclic compounds and methods of their use NOVARTIS AG (CH) 2019-08-06 — — US disclosed
CN-108383999-A Amino-acid modified random copolymers of poly glycol monomethyl ether-polyester-and its preparation method and application 苏州海特比奥生物技术有限公司 2018-08-10 — — CN disclosed
US-20040236102-A1 Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes MERCK SHARP & DOHME CORP. 2004-11-25 — — US disclosed
US-20040110786-A1 4-Oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides as antiviral agents PHARMACIA & UPJOHN COMPANY 2004-06-10 — — US disclosed
EP-1406622-A2 DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES Merck & Co., Inc. (US) 2004-04-14 — — EP disclosed
WO-2004022566-A1 4-OXO-4,7-DIHYDROTHIENO[2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY LLC (US) 2004-03-18 — — WO disclosed
CN-1137886-C 2,3-dioxo-1,2,3,4-tetrahydro-quinoyxalinyl derivatives ��˹��ŵ�� 2004-02-11 — — CN disclosed
WO-2003000181-A2 DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES MERCK & CO., INC. (US) 2003-01-03 — — WO disclosed
CN-1193968-A 2,3-dioxo-1,2,3,4-tetrahydro-quinoyxalinyl derivatives NOVARTIS AG (CH) 1998-09-23 — — CN disclosed
US-4487772-A CARDIOTONIC AGENTS OTSUKA PHARMACEUTICAL CO. LTD. (JP) 1984-12-11 — — US disclosed
US-4468402-A Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1984-08-28 — — US disclosed
US-4454130-A CARDIOTONIC, HYPOTENSIVE AGENTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1984-06-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040110786-A1 4-Oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides as antiviral agents ZC3HAV1, ZC3HAV1L, MAVS POLB 796/4885PLG 4734/4885GBA1 891/4885
US-10370388-B2 Heterocyclic compounds and methods of their use AGTR2, AGTR1, BDKRB2 POLB 2646/4885PLG 2428/4885GBA1 4620/4885
US-11685734-B2 ATM kinase inhibitors and compositions and methods of use thereof ATM, CHEK2, CHEK1 POLB 260/4885PLG 3706/4885GBA1 3258/4885
US-20240067631-A1 PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS NAMPT, NNT, NAPRT POLB 3838/4885PLG 3706/4885GBA1 1760/4885
US-20040236102-A1 Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes DPP4, DPP3, DPP7 POLB 3148/4885PLG 301/4885GBA1 760/4885
US-20210188827-A1 ATM KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF ATM, CHEK2, CHEK1 POLB 260/4885PLG 3706/4885GBA1 3258/4885
US-20240368127-A1 HSD17B13 INHIBITORS AND USES THEREOF HSD17B3, HSD17B11, HSD17B1 POLB 265/4885PLG 1204/4885GBA1 1461/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.