Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 17/20 | 0.53 |
| ▸ | CTSL | P07711 | 9/20 | 0.49 |
| ▸ | CTSK | P43235 | 4/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6691416 | 1.00 | CTSS (0.53) | CTSSCTSLCTSKALOX5EPHX2 | |
| SCHEMBL5359602 | 0.82 | CTSS (0.62) | CTSSCTSLCTSKALOX5EPHX2 | |
| SCHEMBL3024690 | 0.82 | CTSS (0.62) | CTSSCTSLCTSKALOX5EPHX2 | |
| SCHEMBL3014808 | 0.82 | CTSS (0.63) | CTSSCTSLCTSKALOX5EPHX2 | |
| SCHEMBL3014805 | 0.82 | CTSS (0.63) | CTSSCTSLCTSKALOX5EPHX2 | |
| SCHEMBL5362588 | 0.80 | CTSS (0.63) | CTSSCTSLCTSK | |
| SCHEMBL5362596 | 0.78 | CTSS (0.52) | CTSSCTSLCTSKALOX5EPHX2 | |
| SCHEMBL4798807 | 0.77 | CTSS (0.70) | CTSSCTSLCTSK | |
| SCHEMBL4798799 | 0.77 | CTSS (0.70) | CTSSCTSLCTSK | |
| SCHEMBL4800580 | 0.76 | CTSS (0.63) | CTSSCTSLCTSKNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658267-A4 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2007-08-01 | — | — | EP | claimed |
| JP-2007502836-A | — | — | 2007-02-15 | — | — | JP | claimed |
| EP-1658267-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2006-05-24 | — | — | EP | claimed |
| WO-2005034848-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2005-04-21 | — | — | WO | claimed |
| EP-1658267-A4 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2007-08-01 | — | — | EP | disclosed |
| EP-1658267-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005034848-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2005-04-21 | — | — | WO | disclosed |