Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16983040 | 0.99 | ALDH1A1 (0.72) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL7520713 | 0.92 | ALDH1A1 (0.67) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL7522252 | 0.92 | ALDH1A1 (0.71) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL16983013 | 0.91 | ALDH1A1 (0.66) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL16983016 | 0.89 | ALDH1A1 (0.67) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL16975046 | 0.89 | KDM4E (0.64) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL23493807 | 0.85 | ALDH1A1 (1.00) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL2950082 | 0.84 | ALDH1A1 (0.62) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL18000058 | 0.83 | ALDH1A1 (0.64) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL18000068 | 0.82 | ALDH1A1 (0.95) | ALDH1A1KDM4EKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413696-A1 | COMPOSITIONS FOR TREATMENT OF ALZHEIMER'S DISEASE | Mount Sinai School Of Medicine Of New York University (US) | 2012-02-08 | — | — | EP | claimed |
| WO-2010114636-A1 | COMPOSITIONS FOR TREATMENT OF ALZHEIMER'S DISEASE | MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY (US) | 2010-10-07 | — | — | WO | claimed |
| EP-2413696-A1 | COMPOSITIONS FOR TREATMENT OF ALZHEIMER'S DISEASE | Mount Sinai School Of Medicine Of New York University (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114636-A1 | COMPOSITIONS FOR TREATMENT OF ALZHEIMER'S DISEASE | MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY (US) | 2010-10-07 | — | — | WO | disclosed |