Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Toliodium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 6/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Toliodium SCHEMBL125171 | 0.97 | ACHE (0.57) | ACHETDP1ALDH1A1CA2CA1 | |
| Toliodium SCHEMBL3284569 | 0.93 | ACHE (0.53) | ACHETDP1ALDH1A1CA2CA1 | |
| Toliodium SCHEMBL7743288 | 0.93 | ACHE (0.53) | ACHETDP1ALDH1A1CA2CA1 | |
| Toliodium SCHEMBL9296014 | 0.93 | ACHE (0.53) | ACHETDP1ALDH1A1CA2CA1 | |
| Toliodium SCHEMBL125044 | 0.88 | ACHE (0.47) | ACHETDP1ALDH1A1CA2CA1 | |
| SCHEMBL10022958 | 0.88 | ACHE (0.47) | ACHETDP1ALDH1A1CA2CA1 | |
| Toliodium SCHEMBL125045 | 0.88 | ACHE (0.47) | ACHETDP1ALDH1A1CA2CA1 | |
| Toliodium SCHEMBL31513889 | 0.85 | ACHE (0.44) | ACHETDP1ALDH1A1CA2CA1 | |
| Toliodium SCHEMBL29443426 | 0.85 | ACHE (0.44) | ACHETDP1ALDH1A1CA2CA1 | |
| Toliodium SCHEMBL1134117 | 0.85 | ACHE (0.44) | ACHETDP1ALDH1A1CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114891393-A | UV ink for tape measure, preparation method of UV ink and tape measure | 广东阿诺捷喷墨科技有限公司 | 2022-08-12 | — | — | CN | claimed |
| CN-116507342-A | Microcapsule for treating shellfish diseases, preparation method thereof, and composition for treating shellfish diseases containing microcapsule | 弗里西株式会社 | 2023-07-28 | — | — | CN | disclosed |
| CN-114891393-A | UV ink for tape measure, preparation method of UV ink and tape measure | 广东阿诺捷喷墨科技有限公司 | 2022-08-12 | — | — | CN | disclosed |
| CN-114736158-A | Substituted aza [5] helicene derivative and preparation method and application thereof | 苏州大学 | 2022-07-12 | — | — | CN | disclosed |
| CN-114380583-A | Preparation method of ceramic material | 重庆恩辰新材料科技有限责任公司 | 2022-04-22 | — | — | CN | disclosed |
| US-7312014-B2 | Poly(p-hydroxystyrene/styrene/alkyl acrylate) terpolymer derivative and acid generator comprising triphenylsulfonium benzenesulfonate derivative; forming positive pattern using transcription technology in high vacuum with irradiated energy such as electron beam, extreme ultraviolet ray and X-ray | WAKO PURE CHEMICAL INDUSTRIES LTD. (JP) | 2007-12-25 | — | — | US | disclosed |
| US-20040170918-A1 | Poly(p-hydroxystyrene/styrene/alkyl acrylate) terpolymer derivative and acid generator comprising triphenylsulfonium benzenesulfonate derivative; forming positive pattern using transcription technology in high vacuum with irradiated energy such as electron beam, extreme ultraviolet ray and X-ray | WAKO PURE CHEMICAL INDUSTRIES LTD. (JP) | 2004-09-02 | — | — | US | disclosed |
| EP-1406123-A1 | RESIST COMPOSITIONS | Wako Pure Chemical Industries, Ltd. (JP) | 2004-04-07 | — | — | EP | disclosed |
| EP-0119068-B1 | METHOD FOR PREPARING DIARYL IODONIUM SALTS | NIPPON PETROCHEMICALS COMPANY, LIMITED (JP) | 1987-04-22 | — | — | EP | disclosed |
| US-4659840-A | COUPLING AROMATIC HYDROCARBON WITH ARYLIODIDE IN PRESENCE OF SULFURIC ACID AND OXIDIZING AGENT | NIPPON PETROCHEMICALS CO., LTD. (JP) | 1987-04-21 | — | — | US | disclosed |
| EP-0119068-A1 | Method for preparing diaryl iodonium salts | NIPPON PETROCHEMICALS COMPANY, LIMITED (JP) | 1984-09-19 | — | — | EP | disclosed |