Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5409144 | 0.78 | HRH3 (0.59) | NPC1RAB9AKDM4EPKMKMT2A | |
| SCHEMBL4727102 | 0.78 | SMN1; SMN2 (0.79) | NPC1RAB9AKDM4EPKMKMT2A | |
| SCHEMBL5417571 | 0.76 | NPC1 (0.65) | NPC1RAB9AKDM4EPKMKMT2A | |
| SCHEMBL5261256 | 0.76 | NPC1 (0.54) | NPC1RAB9AKDM4EPKMKMT2A | |
| SCHEMBL13325751 | 0.73 | TP53 (0.75) | NPC1RAB9AKDM4EPKMKMT2A | |
| SCHEMBL5257754 | 0.72 | HRH3 (0.60) | NPC1RAB9AKDM4EPKMKMT2A | |
| SCHEMBL5427018 | 0.72 | HRH3 (0.62) | NPC1RAB9AKDM4EPKMKMT2A | |
| SCHEMBL13325910 | 0.71 | SMN1; SMN2 (0.93) | NPC1RAB9AKDM4EPKMKMT2A | |
| SCHEMBL5259851 | 0.71 | HRH3 (0.61) | NPC1RAB9AKDM4EPKMKMT2A | |
| SCHEMBL6544442 | 0.71 | NPC1 (1.00) | NPC1RAB9AKDM4EPKMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050049277-A1 | Phenyl-substituted imidazopyridines | BREITENBUCHER J GUY (US) | 2005-03-03 | — | — | US | claimed |
| US-7199117-B2 | Phenyl-substituted imidazopyridines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-04-03 | — | — | US | disclosed |
| US-7087757-B2 | Phenyl-substituted imidazopyridines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2006-08-08 | — | — | US | disclosed |
| US-6908929-B2 | Phenyl-substituted imidazopyridines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-06-21 | — | — | US | disclosed |
| US-20050085502-A1 | Phenyl-substituted imidazopyridines | BREITENBUCHER J G (US) | 2005-04-21 | — | — | US | disclosed |
| US-20050043348-A1 | Phenyl-substituted imidazopyridines | BREITENBUCHER J GUY (US) | 2005-02-24 | — | — | US | disclosed |
| EP-1268478-A2 | PHENYL-SUBSTITUTED IMIDAZOPYRIDINES | Ortho McNeil Pharmaceutical, Inc. (US) | 2003-01-02 | — | — | EP | disclosed |
| US-20020006934-A1 | Phenyl-substituted imidazopyridines | ORTHO MCNEIL PHARMACEUTICAL, INC. | 2002-01-17 | — | — | US | disclosed |
| WO-2001074815-A2 | PHENYL-SUBSTITUTED IMIDAZOPYRIDINES | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2001-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043348-A1 | Phenyl-substituted imidazopyridines | AADAC, DPP4, DPP3 | NPC1 323/4885RAB9A 3610/4885KDM4E 1467/4885 |
| US-20050085502-A1 | Phenyl-substituted imidazopyridines | AADAC, DPP4, DPP3 | NPC1 323/4885RAB9A 3610/4885KDM4E 1467/4885 |
| US-20050049277-A1 | Phenyl-substituted imidazopyridines | AADAC, DPP4, DPP3 | NPC1 323/4885RAB9A 3610/4885KDM4E 1467/4885 |
| US-20020006934-A1 | Phenyl-substituted imidazopyridines | AADAC, DPP4, DPP3 | NPC1 323/4885RAB9A 3610/4885KDM4E 1467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.