Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 1.00 |
| ▸ | RAB9A | P51151 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | PKM | P14618 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.75 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.72 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.65 |
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6545323 | 0.99 | NPC1 (0.97) | NPC1RAB9AKDM4EPKMTP53 | |
| SCHEMBL13325910 | 0.89 | SMN1; SMN2 (0.93) | NPC1RAB9AKDM4EPKMTP53 | |
| SCHEMBL13325779 | 0.87 | KDM4E (0.78) | NPC1RAB9AKDM4EPKMTP53 | |
| SCHEMBL1691995 | 0.86 | SMN1; SMN2 (1.00) | NPC1RAB9AKDM4EPKMTP53 | |
| SCHEMBL28539546 | 0.85 | KDM4E (0.74) | NPC1RAB9AKDM4EPKMTP53 | |
| SCHEMBL13325818 | 0.85 | KDM4E (0.74) | NPC1RAB9AKDM4EPKMTP53 | |
| SCHEMBL16212302 | 0.84 | RAB9A (0.72) | NPC1RAB9AKDM4EPKMTP53 | |
| SCHEMBL13325729 | 0.84 | NPC1 (0.72) | NPC1RAB9AKDM4EPKMTP53 | |
| SCHEMBL16599930 | 0.84 | TLR9 (1.00) | NPC1RAB9AKDM4EPKMTP53 | |
| Bromide SCHEMBL16600531 | 0.83 | TLR9 (0.97) | NPC1RAB9AKDM4EPKMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109988561-B | Imidazo [1,2-a ] pyridine ratio type pH fluorescent probe and preparation method and application thereof | 上海健康医学院 | 2022-05-10 | — | — | CN | claimed |
| CN-110407835-B | Imidazo [1,2-a ] pyridine near-infrared ratio type pH fluorescent probe and preparation and application thereof | 上海健康医学院 | 2021-04-13 | — | — | CN | claimed |
| US-20040142961-A1 | Utilization of substituted imidazo[1,2-a]-pyridine compounds in pharmaceutical formulations | GRUENENTHAL GMBH (DE) | 2004-07-22 | — | — | US | claimed |
| EP-1372647-A2 | USE OF SUBSTITUTED IMIDAZO 1,2-A]-PYRIDINE COMPOUNDS AS MEDICAMENTS | Grünenthal GmbH (DE) | 2004-01-02 | — | — | EP | claimed |
| WO-2002080914-A2 | USE OF SUBSTITUTED IMIDAZO[1,2-A]-PYRIDINE COMPOUNDS AS MEDICAMENTS | Grünenthal GmbH (DE) | 2002-10-17 | — | — | WO | claimed |
| CN-118290418-A | Method and application of nitrogen-containing heterocyclic compound alkenyl reaction | 广东药科大学 | 2024-07-05 | — | — | CN | disclosed |
| CN-109988561-B | Imidazo [1,2-a ] pyridine ratio type pH fluorescent probe and preparation method and application thereof | 上海健康医学院 | 2022-05-10 | — | — | CN | disclosed |
| CN-108727373-B | Catalytic synthesis method of C-3-aryl seleno-imidazopyridine compound | 青岛科技大学 | 2021-08-20 | — | — | CN | disclosed |
| CN-110407835-B | Imidazo [1,2-a ] pyridine near-infrared ratio type pH fluorescent probe and preparation and application thereof | 上海健康医学院 | 2021-04-13 | — | — | CN | disclosed |
| CN-110407835-B | Imidazo [1,2-a ] pyridine near-infrared ratio type pH fluorescent probe and preparation and application thereof | 上海健康医学院 | 2021-04-13 | — | — | CN | disclosed |
| US-8980887-B2 | 2-aryl imidazo[1,2-a]pyridine-3-acetamide derivatives, preparation methods and uses thereof | INSTITUTE OF PHARMACOLOGY (CN) | 2015-03-17 | — | — | US | disclosed |
| US-20130203754-A1 | 2-Aryl Imidazo[1,2-a]Pyridine-3-Acetamide Derivatives, Preparation Methods and Uses Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2013-08-08 | — | — | US | disclosed |
| CN-103012400-A | Novel synthesis method of pyridino-imidazole compound | UNIV SOOCHOW | 2013-04-03 | — | — | CN | disclosed |
| US-20040142961-A1 | Utilization of substituted imidazo[1,2-a]-pyridine compounds in pharmaceutical formulations | GRUENENTHAL GMBH (DE) | 2004-07-22 | — | — | US | disclosed |
| EP-1372647-A2 | USE OF SUBSTITUTED IMIDAZO 1,2-A]-PYRIDINE COMPOUNDS AS MEDICAMENTS | Grünenthal GmbH (DE) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002080914-A2 | USE OF SUBSTITUTED IMIDAZO[1,2-A]-PYRIDINE COMPOUNDS AS MEDICAMENTS | Grünenthal GmbH (DE) | 2002-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142961-A1 | Utilization of substituted imidazo[1,2-a]-pyridine compounds in pharmaceutical formulations | QDPR, PTGIS, DPYD | NPC1 1374/4885RAB9A 2823/4885KDM4E 2101/4885 |
| US-20130203754-A1 | 2-Aryl Imidazo[1,2-a]Pyridine-3-Acetamide Derivatives, Preparation Methods and Uses Thereof | TSPO, SLC6A1, TBXA2R | NPC1 780/4885RAB9A 2262/4885KDM4E 3821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.