Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 9/20 | 0.34 |
| ▸ | CFTR | P13569 | 4/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5406976 | 0.92 | CYP3A4 (0.41) | ALDH1A1TSHRCYP3A4CYP2C9ALOX15 | |
| SCHEMBL5393632 | 0.84 | ALDH1A1 (0.62) | ALDH1A1TSHRCYP3A4CYP2C9ALOX15 | |
| SCHEMBL5387150 | 0.83 | ALDH1A1 (0.41) | ALDH1A1TSHRCYP3A4CYP2C9ALOX15 | |
| SCHEMBL5405028 | 0.82 | ALDH1A1 (0.37) | ALDH1A1TSHRCYP3A4CYP2C9ALOX15 | |
| SCHEMBL5393777 | 0.82 | ALDH1A1 (0.43) | ALDH1A1TSHRCYP3A4CYP2C9ALOX15 | |
| SCHEMBL5386867 | 0.82 | ALDH1A1 (0.52) | ALDH1A1TSHRCYP3A4CYP2C9ALOX15 | |
| SCHEMBL5389937 | 0.81 | AR (0.44) | ALDH1A1TSHRCYP3A4CYP2C9ALOX15 | |
| SCHEMBL5400065 | 0.80 | ALDH1A1 (0.50) | ALDH1A1TSHRCYP3A4CYP2C9ALOX15 | |
| SCHEMBL5393538 | 0.80 | ALDH1A1 (0.37) | ALDH1A1TSHRCYP3A4CYP2C9ALOX15 | |
| SCHEMBL5398874 | 0.80 | S1PR1 (0.37) | ALDH1A1TSHRCYP3A4CYP2C9ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082643-A1 | Method for the use of pyranoindole derivatives to treat infection with Hepatitis C virus | WYETH (US) | 2004-04-29 | — | — | US | claimed |
| US-7217730-B2 | Method for the use of pyranoindole derivatives to treat infection with Hepatitis C virus | WYETH (US) | 2007-05-15 | — | — | US | disclosed |
| EP-1509225-A1 | METHOD FOR THE USE OF PYRANOINDOLE DERIVATIVES TO TREAT INFECTION WITH HEPATITIS C VIRUS | Wyeth (US) | 2005-03-02 | — | — | EP | disclosed |
| US-20040082643-A1 | Method for the use of pyranoindole derivatives to treat infection with Hepatitis C virus | WYETH (US) | 2004-04-29 | — | — | US | disclosed |
| WO-2003099275-A1 | METHOD FOR THE USE OF PYRANOINDOLE DERIVATIVES TO TREAT INFECTION WITH HEPATITIS C VIRUS | WYETH (US) | 2003-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082643-A1 | Method for the use of pyranoindole derivatives to treat infection with Hepatitis C virus | HAVCR2, HCCS, ZC3HAV1 | ALDH1A1 495/4885TSHR 384/4885CYP3A4 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.