Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5542683 | 0.88 | IDO1 (0.39) | IDO1DAOMRGPRX4MGLLSLC6A4 | |
| SCHEMBL18086871 | 0.85 | IDO1 (0.44) | IDO1DAOMRGPRX4MGLLSLC6A4 | |
| SCHEMBL5546553 | 0.82 | KIF11 (0.45) | IDO1DAO | |
| SCHEMBL5722020 | 0.81 | DAO (0.50) | IDO1DAOMRGPRX4KMONOTUM | |
| SCHEMBL95626 | 0.79 | IDO1 (0.57) | IDO1 | |
| SCHEMBL5536268 | 0.79 | AR (0.45) | IDO1SLC6A4AR | |
| SCHEMBL5541400 | 0.78 | IDO1 (0.49) | IDO1MRGPRX4SLC6A4MAOBPTGDR2 | |
| SCHEMBL5547880 | 0.78 | SCN3A (0.43) | MRGPRX4PTGDR2KMO | |
| SCHEMBL27810116 | 0.78 | SLC6A4 (0.41) | IDO1DAOMRGPRX4SLC6A4MAOB | |
| SCHEMBL2091883 | 0.77 | IDO1 (0.41) | IDO1MAOBNOTUMAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414346-A1 | AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010112124-A1 | AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-07 | — | — | WO | disclosed |