Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | CALML3 | P27482 | 5/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL541170 | 0.93 | DPP4 (0.47) | DPP4DHFRCALML3CHRM2DRD1 | |
| SCHEMBL541976 | 0.93 | DPP4 (0.47) | DPP4DHFRCALML3CHRM2DRD1 | |
| SCHEMBL541619 | 0.87 | KDM4E (0.42) | KDM4ELMNAHSD17B10CYP2C9MAOB | |
| SCHEMBL541774 | 0.85 | CALML3 (0.39) | CALML3LMNACYP2C9CYP2C19MAOA | |
| SCHEMBL541780 | 0.84 | KDM4E (0.40) | CALML3KDM4ELMNAHSD17B10CYP2C9 | |
| SCHEMBL10317154 | 0.84 | KDM4E (0.40) | CALML3KDM4ELMNAHSD17B10CYP2C9 | |
| SCHEMBL541523 | 0.84 | KDM4E (0.40) | CALML3KDM4ELMNAHSD17B10CYP2C9 | |
| SCHEMBL9890813 | 0.84 | DPP4 (0.45) | DPP4DHFRCALML3CHRM2DRD1 | |
| SCHEMBL2109029 | 0.84 | DPP4 (0.45) | DPP4DHFRCALML3CHRM2DRD1 | |
| SCHEMBL2108996 | 0.82 | DPP4 (0.43) | DPP4DHFRCALML3CHRM2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2296651-B1 | 5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES FOR TREATING BACTERIAL INTESTINAL DISEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-07-18 | — | — | EP | claimed |
| EP-2086968-B1 | 5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-02-08 | — | — | EP | claimed |