Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 15/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL541682 | 0.95 | CASR (0.57) | CASRBRD4PPARG | |
| SCHEMBL541683 | 0.95 | CASR (0.57) | CASRBRD4PPARG | |
| SCHEMBL541459 | 0.90 | CASR (0.48) | CASRPPARG | |
| SCHEMBL541458 | 0.90 | CASR (0.48) | CASRPPARG | |
| SCHEMBL541461 | 0.89 | CASR (0.47) | CASRSMN1; SMN2 | |
| SCHEMBL541235 | 0.89 | CASR (0.47) | CASRSMN1; SMN2 | |
| SCHEMBL541227 | 0.87 | CASR (0.58) | CASRPPARGSMN1; SMN2 | |
| SCHEMBL541477 | 0.87 | CASR (0.58) | CASRPPARGSMN1; SMN2 | |
| SCHEMBL541398 | 0.87 | CASR (0.43) | CASRBRD4PPARG | |
| SCHEMBL541388 | 0.87 | CASR (0.43) | CASRBRD4PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509518-B1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC (US) | 2012-02-08 | — | — | EP | claimed |
| US-7176322-B2 | Calcium receptor modulating agents | AMGEN INC. (US) | 2007-02-13 | — | — | US | claimed |
| EP-1509518-B1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC (US) | 2012-02-08 | — | — | EP | disclosed |
| EP-1509518-B1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC (US) | 2012-02-08 | — | — | EP | disclosed |
| US-7176322-B2 | Calcium receptor modulating agents | AMGEN INC. (US) | 2007-02-13 | — | — | US | disclosed |
| US-7176322-B2 | Calcium receptor modulating agents | AMGEN INC. (US) | 2007-02-13 | — | — | US | disclosed |