Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.48 |
| ▸ | ULK1 | O75385 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5413325 | 0.83 | LRRK2 (0.62) | PTK2GSK3BPRKCQLRRK2CYP1A2 | |
| SCHEMBL5418647 | 0.82 | IGF1R (0.59) | GSK3BPRKCQULK1LRRK2CYP1A2 | |
| SCHEMBL5408522 | 0.80 | LRRK2 (0.65) | PTK2GSK3BPRKCQLRRK2PLK1 | |
| SCHEMBL5402268 | 0.79 | GSK3B (0.82) | PTK2GSK3BPRKCQLRRK2CYP1A2 | |
| SCHEMBL5408223 | 0.79 | GSK3B (0.57) | PTK2GSK3BLRRK2CYP1A2PLK1 | |
| SCHEMBL5415291 | 0.78 | HDAC3 (0.49) | PTK2GSK3BPRKCQULK1LRRK2 | |
| SCHEMBL5408687 | 0.77 | IDH2 (0.56) | GSK3BCYP1A2AURKAGSK3AMEN1 | |
| SCHEMBL16134079 | 0.76 | PLK1 (0.48) | PTK2GSK3BLRRK2CYP1A2PLK1 | |
| SCHEMBL1521779 | 0.75 | GSK3B (0.53) | GSK3BPRKCQCYP1A2PLK1AURKA | |
| SCHEMBL5406396 | 0.75 | GSK3B (0.70) | PTK2GSK3BLRRK2CYP1A2PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166599-B2 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2007-01-23 | — | — | US | disclosed |
| US-20050090486-A1 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-04-28 | — | — | US | disclosed |
| US-20030134838-A1 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030134838-A1 | Trisubstituted pyrimidines | APP, PSEN1, BACE1 | PTK2 4485/4885GSK3B 1515/4885PRKCQ 3253/4885 |
| US-20050090486-A1 | Trisubstituted pyrimidines | APP, BACE1, PSEN1 | PTK2 4507/4885GSK3B 790/4885PRKCQ 3437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.