Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.59 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ULK1 | O75385 | 1/20 | 0.52 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5413325 | 0.86 | LRRK2 (0.62) | IGF1RGSK3BLRRK2MAPK1HTT | |
| SCHEMBL5408522 | 0.83 | LRRK2 (0.65) | IGF1RGSK3BLRRK2ALDH1A1LMNA | |
| SCHEMBL5413522 | 0.82 | PTK2 (0.54) | IGF1RGSK3BLRRK2ALDH1A1ULK1 | |
| SCHEMBL5402268 | 0.82 | GSK3B (0.82) | IGF1RGSK3BLRRK2ALDH1A1LMNA | |
| SCHEMBL5408180 | 0.80 | STK17A (0.66) | GSK3BLRRK2LMNAMAPK1PIN1 | |
| SCHEMBL5410032 | 0.79 | GSK3B (0.54) | GSK3BLRRK2PIN1JAK2PLK1 | |
| SCHEMBL5405462 | 0.79 | STK17A (0.51) | IGF1RGSK3BLRRK2PRKCQMEN1 | |
| SCHEMBL5419322 | 0.79 | GSK3B (0.53) | IGF1RGSK3BLRRK2LMNAMAPK1 | |
| SCHEMBL5413375 | 0.78 | PRKCQ (0.64) | IGF1RGSK3BLRRK2PIN1JAK2 | |
| SCHEMBL1521779 | 0.78 | GSK3B (0.53) | GSK3BLMNAPIN1PLK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166599-B2 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2007-01-23 | — | — | US | disclosed |
| US-20050090486-A1 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-04-28 | — | — | US | disclosed |
| US-20030134838-A1 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030134838-A1 | Trisubstituted pyrimidines | APP, PSEN1, BACE1 | IGF1R 1724/4885GSK3B 1515/4885LRRK2 619/4885 |
| US-20050090486-A1 | Trisubstituted pyrimidines | APP, BACE1, PSEN1 | IGF1R 1986/4885GSK3B 790/4885LRRK2 775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.