Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4907603 | 0.93 | IKBKE (0.39) | CHRNA7MEN1KMT2ALMNAMAPT | |
| SCHEMBL4909855 | 0.90 | IKBKE (0.37) | CHRNA7IKBKETBK1 | |
| SCHEMBL4909671 | 0.86 | DAO (0.39) | CHRNA7 | |
| SCHEMBL4909354 | 0.85 | CHRNA7 (0.42) | CHRNA7MEN1KMT2ALMNAMAPT | |
| SCHEMBL4910399 | 0.83 | CD274 (0.42) | — | |
| SCHEMBL5225615 | 0.82 | DAO (0.38) | — | |
| SCHEMBL4907263 | 0.82 | IKBKE (0.44) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL4904828 | 0.81 | DAO (0.41) | — | |
| SCHEMBL4906966 | 0.80 | IKBKE (0.42) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL4903831 | 0.76 | DAO (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861393-A2 | PYRROLE DERIVATIVES AS DNA GYRASE AND TOPOISOMERASE INHIBITORS | AstraZeneca AB (SE) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006092599-A2 | PYRROLE DERIVATIVES AS DNA GYRASE AND TOPOISOMERASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-09-08 | — | — | WO | disclosed |