Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4907603 | 0.93 | IKBKE (0.39) | IKBKETBK1CHRNA7TOP2A | |
| SCHEMBL5225615 | 0.92 | DAO (0.38) | TOP2A | |
| SCHEMBL5414092 | 0.90 | CHRNA7 (0.40) | IKBKETBK1CHRNA7 | |
| SCHEMBL4909671 | 0.86 | DAO (0.39) | CHRNA7TOP2A | |
| SCHEMBL4909354 | 0.85 | CHRNA7 (0.42) | IKBKETBK1CHRNA7 | |
| SCHEMBL4910399 | 0.83 | CD274 (0.42) | — | |
| SCHEMBL4907263 | 0.82 | IKBKE (0.44) | IKBKETBK1TOP2A | |
| SCHEMBL4904828 | 0.81 | DAO (0.41) | TOP2A | |
| SCHEMBL4906966 | 0.80 | IKBKE (0.42) | IKBKETBK1 | |
| SCHEMBL4903831 | 0.76 | DAO (0.39) | TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269214-A1 | Pyrrole Derivatives as Dna Gyrase and Topoisomerase Inhibitors | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | US | claimed |
| US-20080269214-A1 | Pyrrole Derivatives as Dna Gyrase and Topoisomerase Inhibitors | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269214-A1 | Pyrrole Derivatives as Dna Gyrase and Topoisomerase Inhibitors | TOP1, TOP2A, TOP2B | IKBKE 1220/4885TBK1 514/4885CHRNA7 4817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.