Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 5/20 | 0.57 |
| ▸ | NT5E | P21589 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.40 |
| ▸ | HINT1 | P49773 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19837869 | 1.00 | LMNA (0.60) | LMNATP53ALDH1A1MAPTTDP1 | |
| SCHEMBL19843971 | 0.94 | LMNA (0.57) | LMNATP53ALDH1A1MAPTTDP1 | |
| SCHEMBL14264203 | 0.90 | LMNA (0.73) | LMNATP53ALDH1A1MAPTTDP1 | |
| SCHEMBL4450353 | 0.90 | LMNA (0.73) | LMNATP53ALDH1A1MAPTTDP1 | |
| SCHEMBL19837842 | 0.88 | LMNA (0.59) | LMNATP53ALDH1A1MAPTTDP1 | |
| SCHEMBL4213566 | 0.88 | LMNA (0.59) | LMNATP53ALDH1A1MAPTTDP1 | |
| SCHEMBL5415430 | 0.88 | LMNA (0.59) | LMNATP53ALDH1A1MAPTTDP1 | |
| SCHEMBL19837867 | 0.88 | LMNA (0.59) | LMNATP53ALDH1A1MAPTTDP1 | |
| SCHEMBL14559273 | 0.86 | LMNA (0.68) | LMNATP53ALDH1A1MAPTTDP1 | |
| SCHEMBL18179096 | 0.86 | LMNA (0.68) | LMNATP53ALDH1A1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7214665-B2 | 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2007-05-08 | — | — | US | disclosed |