Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | GABBR2 | O75899 | 9/20 | 0.43 |
| ▸ | GABBR1 | Q9UBS5 | 9/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | PDE9A | O76083 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | BRS3 | P32247 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL541600 | 1.00 | KDR (0.45) | KDRAURKBGABBR2GABBR1PDE5A | |
| SCHEMBL12796034 | 0.88 | JAK2 (0.42) | KDRAURKBJAK2JAK1JAK3 | |
| SCHEMBL541571 | 0.88 | MAPT (0.48) | KDRAURKBGABBR2GABBR1JAK2 | |
| SCHEMBL541572 | 0.88 | MAPT (0.48) | KDRAURKBGABBR2GABBR1JAK2 | |
| SCHEMBL6525303 | 0.82 | KDR (0.42) | KDRAURKBGABBR2GABBR1HRH4 | |
| SCHEMBL541609 | 0.82 | KDR (0.42) | KDRAURKBGABBR2GABBR1HRH4 | |
| SCHEMBL6525301 | 0.82 | KDR (0.42) | KDRAURKBGABBR2GABBR1HRH4 | |
| SCHEMBL541610 | 0.82 | KDR (0.42) | KDRAURKBGABBR2GABBR1HRH4 | |
| SCHEMBL541904 | 0.82 | KDR (0.41) | KDRAURKBGABBR2GABBR1JAK2 | |
| SCHEMBL10145269 | 0.82 | KDR (0.41) | KDRAURKBGABBR2GABBR1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130310373-A1 | PYRIMIDINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-11-21 | — | — | US | disclosed |
| US-8524727-B2 | Pyrimidine compound | ASTELLAS PHARMA INC. (JP) | 2013-09-03 | — | — | US | disclosed |
| EP-2415765-A1 | PYRIMIDINE COMPOUND | Astellas Pharma Inc. (JP) | 2012-02-08 | — | — | EP | disclosed |
| US-20110053912-A1 | PYRIMIDINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053912-A1 | PYRIMIDINE COMPOUND | CNR2, CNR1, P2RY2 | KDR 631/4885AURKB 3221/4885GABBR2 254/4885 |
| US-20130310373-A1 | PYRIMIDINE COMPOUND | CNR2, CNR1, P2RY2 | KDR 562/4885AURKB 3462/4885GABBR2 272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.