Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.78 |
| ▸ | ATM | Q13315 | 1/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.78 |
| ▸ | POLB | P06746 | 3/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | BAZ2B | Q9UIF8 | 10/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2483701 | 0.91 | LMNA (0.67) | LMNAPABPC1ATMSMN1; SMN2POLB | |
| SCHEMBL407460 | 0.87 | LMNA (1.00) | LMNAPABPC1ATMSMN1; SMN2POLB | |
| SCHEMBL61901 | 0.87 | LMNA (0.60) | LMNAPABPC1ATMSMN1; SMN2POLB | |
| SCHEMBL3312381 | 0.86 | LMNA (0.57) | LMNAPABPC1ATMSMN1; SMN2POLB | |
| SCHEMBL10777655 | 0.85 | SMN1; SMN2 (0.79) | LMNAPABPC1ATMSMN1; SMN2POLB | |
| SCHEMBL764099 | 0.85 | LMNA (0.79) | LMNAPABPC1ATMSMN1; SMN2POLB | |
| SCHEMBL12868340 | 0.85 | LMNA (0.79) | LMNAPABPC1ATMSMN1; SMN2POLB | |
| SCHEMBL12868564 | 0.84 | LMNA (0.78) | LMNAPABPC1ATMSMN1; SMN2POLB | |
| SCHEMBL620615 | 0.83 | LMNA (0.87) | LMNAPABPC1ATMSMN1; SMN2POLB | |
| SCHEMBL940424 | 0.82 | LMNA (0.74) | LMNAPABPC1ATMSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509518-B1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC (US) | 2012-02-08 | — | — | EP | disclosed |
| US-7176322-B2 | Calcium receptor modulating agents | AMGEN INC. (US) | 2007-02-13 | — | — | US | disclosed |
| EP-1509518-A1 | CALCIUM RECEPTOR MODULATING AGENTS | Amgen, Inc. (US) | 2005-03-02 | — | — | EP | disclosed |
| US-20040077619-A1 | Calcium receptor modulating agents | AMGEN INC. | 2004-04-22 | — | — | US | disclosed |
| WO-2003099814-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN, INC. (US) | 2003-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077619-A1 | Calcium receptor modulating agents | PTH1R, CASR, CALCR | LMNA 3732/4885PABPC1 4292/4885ATM 4317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.