Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 11/20 | 0.61 |
| ▸ | PPARG | P37231 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL541645 | 1.00 | CASR (0.61) | CASRPPARGSMN1; SMN2PDE4APDE4B | |
| SCHEMBL541461 | 0.91 | CASR (0.47) | CASRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL541235 | 0.91 | CASR (0.47) | CASRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL3946612 | 0.90 | CASR (0.49) | CASRPPARGSMN1; SMN2PDE4APDE4B | |
| SCHEMBL542073 | 0.90 | CASR (0.49) | CASRPPARGSMN1; SMN2PDE4APDE4B | |
| SCHEMBL541602 | 0.87 | CASR (0.55) | CASRPPARGSMN1; SMN2MEN1KMT2A | |
| SCHEMBL541603 | 0.87 | CASR (0.55) | CASRPPARGSMN1; SMN2MEN1KMT2A | |
| SCHEMBL541858 | 0.86 | CASR (0.46) | CASRPPARGPTGES | |
| SCHEMBL541327 | 0.86 | CASR (0.46) | CASRPPARGPTGES | |
| SCHEMBL541529 | 0.84 | CASR (0.43) | CASRPPARGSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509518-B1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC (US) | 2012-02-08 | — | — | EP | claimed |