Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.49 |
| ▸ | RAF1 | P04049 | 7/20 | 0.49 |
| ▸ | KDR | P35968 | 14/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 9/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | STK25 | O00506 | 1/20 | 0.45 |
| ▸ | CIT | O14578 | 1/20 | 0.45 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | GAK | O14976 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | MUSK | O15146 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5333931 | 0.84 | KDR (0.61) | BRAFRAF1KDRPDGFRBKIT | |
| SCHEMBL5343043 | 0.81 | KDR (0.60) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL5424039 | 0.78 | KDR (0.62) | BRAFRAF1KDRRETCDK8 | |
| SCHEMBL5419476 | 0.77 | KDR (0.54) | BRAFKDRMAPK14TNNI3KMAP2K7 | |
| SCHEMBL5345003 | 0.77 | KDR (0.47) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL5341654 | 0.76 | KDR (0.54) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL5338822 | 0.75 | KDR (0.45) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL14447566 | 0.74 | MAP4K4 (0.41) | BRAFKDRMAPK14TNNI3KMAP2K7 | |
| SCHEMBL5450897 | 0.73 | RAF1 (0.56) | BRAFRAF1KDR | |
| SCHEMBL5350860 | 0.72 | KDR (0.62) | BRAFRAF1KDRMAPK14TNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076473-A2 | SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES | KALYPSYS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| US-20070155764-A1 | NOVEL SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES | KALYPSYS, INC. (US) | 2007-07-05 | — | — | US | disclosed |
| US-20070155764-A1 | NOVEL SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES | KALYPSYS, INC. (US) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155764-A1 | NOVEL SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES | BRAF, ARAF, RAF1 | BRAF 1/4885RAF1 3/4885KDR 555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.