Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.45 |
| ▸ | TNNI3K | Q59H18 | 11/20 | 0.45 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.40 |
| ▸ | BRAF | P15056 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5340417 | 0.88 | MAP2K7 (0.46) | KDRTNNI3KMAP2K7NPC1RAB9A | |
| SCHEMBL14447566 | 0.85 | MAP4K4 (0.41) | KDRTNNI3KMAP2K7MAPK14BRAF | |
| SCHEMBL5333931 | 0.80 | KDR (0.61) | KDRBRAFRAF1 | |
| SCHEMBL5444260 | 0.79 | RAB9A (0.42) | NPC1RAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5419476 | 0.77 | KDR (0.54) | KDRTNNI3KMAP2K7MAPK14BRAF | |
| SCHEMBL5420322 | 0.75 | BRAF (0.49) | KDRTNNI3KMAP2K7MAPK14BRAF | |
| SCHEMBL5318118 | 0.75 | KDR (0.54) | KDRTNNI3KMAP2K7MAPK14BRAF | |
| SCHEMBL14447617 | 0.74 | MAP2K7 (0.43) | KDRTNNI3KMAP2K7MAPK14BRAF | |
| SCHEMBL5337979 | 0.74 | KDR (0.46) | KDRTNNI3KMAP2K7MAPK14BRAF | |
| SCHEMBL5424685 | 0.74 | KDR (0.48) | KDRTNNI3KMAP2K7MAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070155764-A1 | NOVEL SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES | KALYPSYS, INC. (US) | 2007-07-05 | — | — | US | disclosed |
| WO-2007076473-A2 | SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES | KALYPSYS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155764-A1 | NOVEL SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES | BRAF, ARAF, RAF1 | KDR 555/4885TNNI3K 112/4885MAP2K7 141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.