Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2B | Q02880 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | HPGD | P15428 | 7/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL541319 | 0.92 | TOP2B (0.54) | TOP2BALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL541403 | 0.92 | TOP2B (0.54) | TOP2BALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL541349 | 0.90 | KDM4E (0.44) | TOP2BALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL541114 | 0.86 | KDM4E (0.42) | TOP2BALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL541790 | 0.86 | KDM4E (0.42) | TOP2BALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL541378 | 0.83 | KDM4E (0.54) | TOP2BALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL541348 | 0.83 | KDM4E (0.54) | TOP2BALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL542133 | 0.81 | KDM4E (0.40) | TOP2BALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL541789 | 0.80 | KDM4E (0.51) | TOP2BALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL541113 | 0.80 | KDM4E (0.51) | TOP2BALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086968-B1 | 5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-02-08 | — | — | EP | claimed |