Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.34 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL318002 | 0.92 | ESR2 (0.45) | ESR2MAPTSMN1; SMN2LMNAHSD17B1 | |
| SCHEMBL10109098 | 0.92 | ESR2 (0.45) | ESR2MAPTSMN1; SMN2LMNAHSD17B1 | |
| SCHEMBL318352 | 0.83 | ESR2 (0.45) | ESR2MAPTSMN1; SMN2LMNAHSD17B1 | |
| SCHEMBL10109045 | 0.83 | ESR2 (0.45) | ESR2MAPTSMN1; SMN2LMNAHSD17B1 | |
| SCHEMBL10108815 | 0.75 | ESR2 (0.49) | ESR2MAPTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL317798 | 0.75 | ESR2 (0.49) | ESR2MAPTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL10108855 | 0.75 | ESR2 (0.49) | ESR2MAPTSMN1; SMN2LMNAHSD17B1 | |
| SCHEMBL319627 | 0.75 | ESR2 (0.49) | ESR2MAPTSMN1; SMN2LMNAHSD17B1 | |
| SCHEMBL10109092 | 0.69 | LMNA (0.43) | MAPTSMN1; SMN2LMNAHSD17B1RECQL | |
| SCHEMBL318041 | 0.69 | LMNA (0.43) | MAPTSMN1; SMN2LMNAHSD17B1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853578-A1 | SUBSTITUTED TETRALINS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | ELI LILLY AND COMPANY (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006088716-A1 | SUBSTITUTED TETRALINS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | ELI LILLY AND COMPANY (US) | 2006-08-24 | — | — | WO | disclosed |