Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP5 | Q13451 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313445 | 0.94 | — | — | |
| SCHEMBL3665840 | 0.68 | FKBP5 (0.32) | FKBP5CRBN | |
| SCHEMBL1155690 | 0.67 | — | — | |
| SCHEMBL2042183 | 0.66 | — | — | |
| SCHEMBL12111262 | 0.64 | FKBP5 (0.36) | FKBP5CRBNUHRF1 | |
| SCHEMBL503315 | 0.63 | CHRM5 (0.37) | — | |
| SCHEMBL25251015 | 0.61 | FKBP5 (0.33) | FKBP5CRBNUHRF1 | |
| SCHEMBL2051773 | 0.61 | — | — | |
| SCHEMBL2050084 | 0.61 | — | — | |
| SCHEMBL14181105 | 0.61 | FKBP5 (0.33) | FKBP5CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414340-A1 | COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114971-A1 | COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF | SEPRACOR INC. (US) | 2010-10-07 | — | — | WO | disclosed |