SCHEMBL542159

SCHEMBL542159

CC(=O)c1cc(Cl)sc1Cl

nearest known ligand 0.65

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DAO P14920 2/20 0.65
RAB9A P51151 3/20 0.62
SMN1; SMN2 Q16637 3/20 0.62
MAPT P10636 2/20 0.62
NPC1 O15118 1/20 0.62
GSK3B P49841 1/20 0.59
HPGD P15428 3/20 0.58
L3MBTL1 Q9Y468 2/20 0.58
KDM4E B2RXH2 1/20 0.58
MAPK1 P28482 1/20 0.51
HTT P42858 1/20 0.51
KMT2A Q03164 1/20 0.46
POLB P06746 1/20 0.46
MAOA P21397 1/20 0.44
MAOB P27338 1/20 0.44
KDR P35968 3/20 0.38
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11880888 0.84 RAB9A (0.49) DAORAB9ASMN1; SMN2MAPTNPC1
SCHEMBL11844863 0.81 DAO (0.71) DAORAB9ASMN1; SMN2MAPTNPC1
SCHEMBL23151886 0.80 MAPT (0.47) DAORAB9ASMN1; SMN2MAPTNPC1
SCHEMBL377802 0.79 DAO (0.68) DAORAB9ASMN1; SMN2MAPTNPC1
SCHEMBL792551 0.79 DAO (1.00) DAORAB9ASMN1; SMN2MAPTNPC1
SCHEMBL9407745 0.78 RAB9A (0.46) DAORAB9ASMN1; SMN2MAPTNPC1
SCHEMBL31139879 0.78 MAPT (0.46) DAORAB9ASMN1; SMN2MAPTNPC1
SCHEMBL2063137 0.78 DAO (0.61) DAORAB9ASMN1; SMN2MAPTNPC1
SCHEMBL28636581 0.78 RAB9A (0.50) DAORAB9ASMN1; SMN2MAPTNPC1
SCHEMBL14434109 0.77 DAO (0.54) DAORAB9ASMN1; SMN2MAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 134 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119874697-A Preparation method of thiazole amide derivative and application of thiazole amide derivative in treatment of inflammation 成都大学 2025-04-25 CN claimed
CN-117486872-A Mechanical ball milling synthesis method of aminothiazole compound 浙江工业大学 2024-02-02 CN claimed
CN-110759888-A Synthetic method of 3-acetyl-2, 5-dichlorothiophene 山东省化工研究院 2020-02-07 CN claimed
CN-102797043-B Medicinal molecular fragment library and construction process thereof Tianli (Tianjin) Technology Co., Ltd. (CN) 2015-11-25 CN claimed
EP-0617038-B1 Preparation of carbonic anhydrase inhibitors ALCON LAB INC (US) 2001-09-05 EP claimed
US-6096124-A Ink compositions XEROX CORPORATION (US) 2000-08-01 US claimed
EP-0617038-A1 Preparation of carbonic anhydrase inhibitors ALCON LABORATORIES, INC. (US) 1994-09-28 EP claimed
US-5344929-A Preparation of carbonic anhydrase inhibitors ALCON LABORATORIES, INC. (US) 1994-09-06 US claimed
JP-7002835-A None JP disclosed
US-20250340532-A1 HETEROCYCLIC COMPOUND CCR4 INHIBITOR AND USER THEREOF XIZANG HAISCO PHARMACEUTICAL CO LTD (CN) 2025-11-06 US disclosed
CN-119874697-A Preparation method of thiazole amide derivative and application of thiazole amide derivative in treatment of inflammation 成都大学 2025-04-25 CN disclosed
CN-119874697-A Preparation method of thiazole amide derivative and application of thiazole amide derivative in treatment of inflammation 成都大学 2025-04-25 CN disclosed
EP-4534534-A1 HETEROCYCLIC COMPOUND CCR4 INHIBITOR AND USER THEREOF Xizang Haisco Pharmaceutical Co., Ltd. (CN) 2025-04-09 EP disclosed
CN-117486872-A Mechanical ball milling synthesis method of aminothiazole compound 浙江工业大学 2024-02-02 CN disclosed
EP-0202903-A2 Control of ectoparasites ELI LILLY AND COMPANY (US) 1986-11-26 EP disclosed
EP-0187711-A2 Octahydroindolizine compounds useful as analgesics McNeilab, Inc. (US) 1986-07-16 EP disclosed
US-4582836-A Octahydroindolizine compounds useful as analgesics MCNEILAB, INC. (US) 1986-04-15 US disclosed
US-4558045-A CARDIOTONIC AND HYPOTENSIVE ACTIVITY IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) 1985-12-10 US disclosed
US-4489073-A HYPOTENSIVE AND CARDIOTONIC AGENTS IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) 1984-12-18 US disclosed
EP-0085227-A1 Thiadiazine derivatives, and pharmaceutical compositions containing them IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-08-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250340532-A1 HETEROCYCLIC COMPOUND CCR4 INHIBITOR AND USER THEREOF CCR4, CCR1, CCR3 DAO 3386/4885RAB9A 2964/4885SMN1; SMN2 1941/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.