Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 6/20 | 0.34 |
| ▸ | TMPRSS2 | O15393 | 4/20 | 0.34 |
| ▸ | HPN | P05981 | 4/20 | 0.34 |
| ▸ | ST14 | Q9Y5Y6 | 4/20 | 0.34 |
| ▸ | HGFAC | Q04756 | 2/20 | 0.34 |
| ▸ | F10 | P00742 | 3/20 | 0.34 |
| ▸ | PLG | P00747 | 2/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | PROC | P04070 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2186464 | 0.87 | HDAC3 (0.48) | F2TMPRSS2HPNST14HGFAC | |
| SCHEMBL12214923 | 0.76 | HDAC3 (0.48) | F2TMPRSS2HPNST14HGFAC | |
| SCHEMBL14597656 | 0.75 | HDAC3 (0.51) | F2TMPRSS2HPNST14HGFAC | |
| SCHEMBL12214853 | 0.75 | HDAC3 (0.52) | F2TMPRSS2HPNST14HGFAC | |
| SCHEMBL14847433 | 0.75 | HDAC3 (0.52) | F2TMPRSS2HPNST14HGFAC | |
| SCHEMBL12214828 | 0.75 | HDAC3 (0.52) | F2TMPRSS2HPNST14HGFAC | |
| Hydrochloric Acid SCHEMBL2357315 | 0.74 | HDAC3 (0.51) | F2TMPRSS2HPNST14HGFAC | |
| Hydrochloric Acid SCHEMBL2357318 | 0.74 | HDAC3 (0.51) | F2TMPRSS2HPNST14HGFAC | |
| Hydrochloric Acid SCHEMBL2358557 | 0.74 | HDAC3 (0.51) | F2TMPRSS2HPNST14HGFAC | |
| Hydrochloric Acid SCHEMBL4407501 | 0.74 | HDAC3 (0.49) | F2TMPRSS2HPNST14HGFAC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412336-A4 | PEPTOID COMPOUNDS | UNIV WOLLONGONG (AU) | 2007-08-29 | — | — | EP | disclosed |
| EP-1412336-A1 | PEPTOID COMPOUNDS | UNIVERSITY OF WOLLONGONG (AU) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003002545-A1 | PEPTOID COMPOUNDS | UNIVERSITY OF WOLLONGONG (AU) | 2003-01-09 | — | — | WO | disclosed |