Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.57 |
| ▸ | HTR2A | P28223 | 5/20 | 0.54 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.45 |
| ▸ | TUBB | P07437 | 1/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5424650 | 0.89 | HTR2A (0.55) | OPRM1OPRK1HTR2ATLR9KDM4E | |
| SCHEMBL5434438 | 0.88 | HTR2A (0.62) | OPRM1OPRK1HTR2ATLR9POLB | |
| SCHEMBL5421052 | 0.88 | HTR2A (0.52) | OPRM1OPRK1HTR2ATLR9OPRL1 | |
| Hydrochloric Acid SCHEMBL5417603 | 0.87 | HTR2A (0.51) | OPRM1OPRK1HTR2ATLR9OPRL1 | |
| SCHEMBL5425307 | 0.86 | HTR1A (0.51) | HTR2ATLR9POLBKDM4EHSD17B10 | |
| SCHEMBL5434473 | 0.82 | HTR2A (0.47) | OPRM1OPRK1HTR2ATLR9POLB | |
| SCHEMBL947686 | 0.81 | POLB (0.64) | HTR2APOLBKDM4EGAAMAPT | |
| SCHEMBL5420550 | 0.81 | HTR2A (0.52) | OPRM1OPRK1HTR2AKDM4EMAPT | |
| SCHEMBL5430112 | 0.80 | HTR2A (0.54) | OPRM1OPRK1HTR2ATLR9OPRL1 | |
| SCHEMBL4522438 | 0.80 | HTR2A (0.65) | OPRM1OPRK1HTR2ATLR9DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197603-A1 | Substituted indole ligands for the orl-1 receptor | GLAXOSMITHKLINE S.P.A. (IT) | 2007-08-23 | — | — | US | claimed |
| US-20070197603-A1 | Substituted indole ligands for the orl-1 receptor | GLAXOSMITHKLINE S.P.A. (IT) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197603-A1 | Substituted indole ligands for the orl-1 receptor | OGFRL1, OPRL1, ORMDL3 | OPRM1 10/4885OPRK1 5/4885HTR2A 147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.