Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 13/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | OXTR | P30559 | 1/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1466224 | 0.98 | AVPR1B (0.53) | AVPR1BALDH1A1MEN1KMT2AOXTR | |
| SCHEMBL1466321 | 0.94 | AVPR1B (0.47) | AVPR1BALDH1A1MEN1KMT2AOXTR | |
| SCHEMBL1465084 | 0.93 | AVPR1B (0.59) | AVPR1BALDH1A1MEN1KMT2AOXTR | |
| Hydrochloric Acid SCHEMBL1465353 | 0.92 | AVPR1B (0.54) | AVPR1BALDH1A1MEN1KMT2AOXTR | |
| SCHEMBL1464977 | 0.89 | AVPR1B (0.60) | AVPR1BALDH1A1MEN1KMT2AOXTR | |
| SCHEMBL1466418 | 0.88 | AVPR1B (0.49) | AVPR1BALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL1464290 | 0.88 | AVPR1B (0.56) | AVPR1BALDH1A1OXTRAVPR1AMAPT | |
| SCHEMBL1795556 | 0.88 | AVPR1B (0.43) | AVPR1BALDH1A1KMT2AOXTRAVPR1A | |
| SCHEMBL1465359 | 0.87 | AVPR1B (0.58) | AVPR1BMEN1KMT2AOXTRAVPR1A | |
| SCHEMBL1464848 | 0.87 | AVPR1B (0.57) | AVPR1BALDH1A1OXTRAVPR1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667993-B1 | HETEROARYL-SUBSTITUTED 1,3-DIHYDROINDOL-2-ONE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | ABBVIE DEUTSCHLAND (DE) | 2015-07-01 | — | — | EP | claimed |
| US-20070021607-A1 | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them | ABBOTT GMBH & CO. KG. | 2007-01-25 | — | — | US | disclosed |
| US-20050070718-A1 | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them | ABBOTT GMBH & CO. KG | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070718-A1 | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them | OXTR, AVPR2, AVPR1A | AVPR1B 4/4885ALDH1A1 886/4885MEN1 259/4885 |
| US-20070021607-A1 | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them | OXTR, AVPR2, AVPR1A | AVPR1B 4/4885ALDH1A1 886/4885MEN1 259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.