Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.41 |
| ▸ | TDP2 | O95551 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.33 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5424708 | 1.00 | RET (0.41) | RETTDP2MAPTALDH1A1KDM4E | |
| SCHEMBL5434452 | 0.86 | MAOA (0.43) | RETMAP4K4GSK3BCLK4RPS6KA3 | |
| SCHEMBL5434450 | 0.86 | MAOA (0.43) | RETMAP4K4GSK3BCLK4RPS6KA3 | |
| SCHEMBL7614310 | 0.83 | JAK3 (0.35) | RETTDP2MAPTALDH1A1KDM4E | |
| SCHEMBL7614312 | 0.83 | JAK3 (0.35) | RETTDP2MAPTALDH1A1KDM4E | |
| SCHEMBL4862659 | 0.81 | EGFR (0.46) | MAPTALDH1A1KDM4ENPSR1GSK3B | |
| SCHEMBL4862653 | 0.81 | EGFR (0.46) | MAPTALDH1A1KDM4ENPSR1GSK3B | |
| SCHEMBL5421094 | 0.78 | RET (0.40) | RETTDP2MAPTALDH1A1KDM4E | |
| SCHEMBL5421090 | 0.78 | RET (0.40) | RETTDP2MAPTALDH1A1KDM4E | |
| SCHEMBL5430267 | 0.76 | RET (0.41) | RETTDP2MAP4K4GSK3BCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350747-B1 | PROTEIN SERINE/THREONINE KINASE AND PROTEIN TYROSINE KINASE ENZYME INHIBITORS; ANGIOGENESIS INHIBITORS; ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | GLAXO WELLCOME INC. | 2002-02-26 | — | — | US | claimed |
| US-20070213403-A1 | TAMOXIFEN RESPONSE IN PRE-AND POSTMENOPAUSAL BREAST CANCER PATIENTS | FORSKARPATENT I SYD AB (SE) | 2007-09-13 | — | — | US | disclosed |