Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 16/20 | 0.59 |
| ▸ | HSD11B2 | P80365 | 10/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL233196 | 0.92 | HSD11B1 (0.69) | HSD11B1HSD11B2LMNAHTT | |
| SCHEMBL233346 | 0.87 | HSD11B1 (0.62) | HSD11B1HSD11B2 | |
| SCHEMBL2822072 | 0.84 | HSD11B1 (0.56) | HSD11B1HSD11B2LMNAHTT | |
| SCHEMBL2822068 | 0.84 | HSD11B1 (0.56) | HSD11B1HSD11B2LMNAHTT | |
| SCHEMBL234701 | 0.82 | HSD11B1 (0.76) | HSD11B1HSD11B2 | |
| SCHEMBL233235 | 0.81 | HSD11B1 (0.64) | HSD11B1HSD11B2 | |
| SCHEMBL253075 | 0.81 | HSD11B1 (0.59) | HSD11B1HSD11B2 | |
| SCHEMBL231274 | 0.80 | HSD11B1 (0.65) | HSD11B1HSD11B2LMNAALDH1A1 | |
| SCHEMBL15899906 | 0.80 | HSD11B1 (0.53) | HSD11B1HSD11B2LMNAALDH1A1HTT | |
| SCHEMBL2828364 | 0.79 | HSD11B1 (0.51) | HSD11B1HSD11B2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751108-A1 | ADAMANTYL-ACETAMIDE DERIVATIVES AS INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2007-02-14 | — | — | EP | claimed |
| WO-2005108368-A1 | ADAMANTYL-ACETAMIDE DERIVATIVES AS INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2005-11-17 | — | — | WO | claimed |