SCHEMBL5425293

SCHEMBL5425293

C[Si](C)(C)c1ccc(-c2ccc([Si](C)(C)C)cc2Br)c(Br)c1

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.33
NR1H2 P55055 1/20 0.31
NR1H3 Q13133 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14371941 0.80 ACHE (0.33) ACHENR1H2NR1H3
SCHEMBL12413420 0.76
SCHEMBL28749102 0.76 ACHE (0.32) ACHE
SCHEMBL1040241 0.76 ACHE (0.35) ACHENR1H2NR1H3
SCHEMBL1077885 0.73 NOTUM (0.46) ACHENR1H2NR1H3
SCHEMBL16558528 0.71 KDM1A (0.37) ACHENR1H2NR1H3
SCHEMBL16550138 0.71 POLB (0.34) ACHE
SCHEMBL1041820 0.71 KDM1A (0.37) ACHENR1H2NR1H3
SCHEMBL7636050 0.70 ACHE (0.33) ACHENR1H2NR1H3
SCHEMBL1042014 0.69 NOTUM (0.47) ACHENR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11183648-B2 Polymers, their preparation and uses CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2021-11-23 US disclosed
US-20160343961-A1 POLYMERS, THEIR PREPARATION AND USES CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2016-11-24 US disclosed
US-20160343961-A1 POLYMERS, THEIR PREPARATION AND USES CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2016-11-24 US disclosed
US-20160343961-A1 POLYMERS, THEIR PREPARATION AND USES CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2016-11-24 US disclosed
US-9419233-B2 Polymers, their preparation and uses CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2016-08-16 US disclosed
US-9419233-B2 Polymers, their preparation and uses CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2016-08-16 US disclosed
US-9419233-B2 Polymers, their preparation and uses CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2016-08-16 US disclosed
US-20130334505-A1 Polymers, Their Preparation and Uses CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED (GB) 2013-12-19 US disclosed
EP-1682600-B1 DIBENZOSILOL POLYMERS, THEIR PREPARATION AND USES CAMBRIDGE DISPLAY TECH LTD (GB) 2013-01-23 EP disclosed
US-20070248839-A1 Dibenzosilol Polymers, Their Preparation and Uses CAMBRIDGE ENTERPRISE LIMITED (GB) 2007-10-25 US disclosed
US-20070248839-A1 Dibenzosilol Polymers, Their Preparation and Uses CAMBRIDGE ENTERPRISE LIMITED (GB) 2007-10-25 US disclosed
EP-1682600-A1 DIBENZOSILOL POLYMERS, THEIR PREPARATION AND USES Cambridge Display Technology Limited (GB) 2006-07-26 EP disclosed
WO-2005047363-A1 DIBENZOSILOL POLYMERS, THEIR PREPARATION AND USES CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2005-05-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160343961-A1 POLYMERS, THEIR PREPARATION AND USES PARG, PARP1, PCBP1 ACHE 4015/4885NR1H2 2633/4885NR1H3 2155/4885
US-11183648-B2 Polymers, their preparation and uses PARG, PARP1, PCBP1 ACHE 4015/4885NR1H2 2633/4885NR1H3 2155/4885
US-20070248839-A1 Dibenzosilol Polymers, Their Preparation and Uses PARG, PCBP1, RAD54L ACHE 4172/4885NR1H2 2547/4885NR1H3 2046/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.