Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | ATR | Q13535 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5425953 | 0.70 | LRRK2 (0.45) | LRRK2PIK3CAALDH1A1KDM4EHPGD | |
| SCHEMBL27492558 | 0.67 | ATR (0.41) | LRRK2PIK3CAALDH1A1KDM4EAURKA | |
| SCHEMBL21384371 | 0.66 | TP53 (0.47) | PIK3CAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL21921211 | 0.66 | LRRK2 (0.52) | LRRK2ALDH1A1KDM4EHPGDCYP1A2 | |
| SCHEMBL12179269 | 0.66 | LRRK2 (0.52) | LRRK2ALDH1A1KDM4EHPGDCYP1A2 | |
| SCHEMBL3436634 | 0.66 | CYP1A2 (0.56) | LRRK2PIK3CAALDH1A1MAPK1CYP1A2 | |
| SCHEMBL4424393 | 0.65 | AURKA (0.52) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL5466087 | 0.65 | POLB (0.52) | LRRK2PIK3CAALDH1A1KDM4EMAPK1 | |
| SCHEMBL30855570 | 0.65 | POLB (0.52) | LRRK2PIK3CAALDH1A1KDM4EMAPK1 | |
| SCHEMBL27366311 | 0.65 | TP53 (0.39) | LRRK2PIK3CAALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070219229-A1 | Pyrrolopyridine Derivatives | GLAXO GROUP LIMITED (GB) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219229-A1 | Pyrrolopyridine Derivatives | CNR2, CNR1, TRPV1 | LRRK2 2128/4885PIK3CA 531/4885ALDH1A1 3093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.