Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 4/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ATRIP | Q8WXE1 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8405325 | 0.87 | TP53 (0.52) | TP53PIK3CAPKMPOLBUSP2 | |
| SCHEMBL27492558 | 0.84 | ATR (0.41) | TP53PIK3CAATRLRRK2PKM | |
| SCHEMBL8408363 | 0.76 | MEN1 (0.47) | TP53PKMUSP2MAPK1RECQL | |
| SCHEMBL8568662 | 0.74 | PKM (0.55) | TP53PIK3CAPKMPOLBUSP2 | |
| SCHEMBL27447787 | 0.68 | AURKA (0.41) | TP53POLBMAPK1AURKAMAPT | |
| SCHEMBL353809 | 0.67 | KMT2A (0.65) | TP53PIK3CAPKMPOLBMAPK1 | |
| SCHEMBL29574622 | 0.67 | KMT2A (0.65) | TP53PIK3CAPKMPOLBMAPK1 | |
| SCHEMBL5425955 | 0.65 | LRRK2 (0.42) | TP53PIK3CAATRLRRK2ATRIP | |
| SCHEMBL5425953 | 0.65 | LRRK2 (0.45) | PIK3CALRRK2POLBMAPK1RECQL | |
| Nitrous Acid SCHEMBL28573054 | 0.63 | KMT2A (0.59) | PIK3CAPKMPOLBMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1066446-C | 4-amino-3-acylnaphthyridine derivatives | YUNGJIN PHARMACEUTICAL CO LTD (KR) | 2001-05-30 | — | — | CN | disclosed |